INT250248

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AQP4, SLC1A3) transmembrane transport (AQP4, SLC1A3) transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
astrocytes 1
AQP4 (Homo sapiens)
SLC1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 60 99.42 Very High Very High Very High
Central nervous system 84 98.66 Very High Very High Very High
Glutamate 216 94.40 High High
Multiple sclerosis 32 15.68 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
Glutamate receptor 16 5.00 Very Low Very Low Very Low
excitatory amino acid 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 348 95.44 Very High Very High Very High
Demyelinating Disease 60 15.68 Low Low
INFLAMMATION 32 5.00 Very Low Very Low Very Low
Toxicity 20 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Autoimmune Disease 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our immunohistochemical analysis of nonpathologic human CNS tissue (both cortical and spinal cord) reveal that EAAT2, but not EAAT1, normally colocalizes with AQP4 in gray matter astrocytes (Fig. 5 A) and that EAAT2 is most enriched in spinal cord gray matter (Fig. 5 B, top).
AQP4 Binding (colocalizes) of EAAT1 in astrocytes associated with central nervous system and spinal cord
1) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.43 Pain Relevance 0.34
These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.


AQP4 Binding (complex) of EAAT1
2) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17
These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.
AQP4 Binding (association) of EAAT1
3) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.08
These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.


AQP4 Binding (complex) of EAAT1
4) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17

General Comments

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