INT250251

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.12 Pain Relevance 0.43

plasma membrane (SLC1A2, SLC1A3) transmembrane transport (SLC1A2, SLC1A3)

SLC1A2 (Homo sapiens) SLC1A3 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 63 96.88 Glutamate 162 89.68 Spinal cord 45 60.32 Multiple sclerosis 24 5.00 Inflammation 21 5.00 Glutamate receptor 12 5.00 excitatory amino acid 6 5.00 Demyelination 6 5.00 anesthesia 3 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 261 95.44 Demyelinating Disease 45 5.00 INFLAMMATION 24 5.00 Toxicity 15 5.00 Targeted Disruption 9 5.00 Neurodegenerative Disease 9 5.00 Autoimmune Disease 9 5.00 Pressure And Volume Under Development 6 5.00 Necrosis 3 5.00 Disease Progression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.

EAAT2 Binding (complex) of EAAT1

1) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17

These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.

EAAT2 Binding (association) of EAAT1

2) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.08

These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.

EAAT2 Binding (complex) of EAAT1

3) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17

General Comments

This test has worked.