INT250251

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A2, SLC1A3) transmembrane transport (SLC1A2, SLC1A3)
SLC1A2 (Homo sapiens)
SLC1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 63 96.88 Very High Very High Very High
Glutamate 162 89.68 High High
Spinal cord 45 60.32 Quite High
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
Inflammation 21 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
excitatory amino acid 6 5.00 Very Low Very Low Very Low
Demyelination 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 261 95.44 Very High Very High Very High
Demyelinating Disease 45 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Autoimmune Disease 9 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.


EAAT2 Binding (complex) of EAAT1
1) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17
These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.
EAAT2 Binding (association) of EAAT1
2) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.08
These results support the existence of AQP4 and EAAT2 as a macromolecular complex independent of EAAT1.


EAAT2 Binding (complex) of EAAT1
3) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.22 Pain Relevance 0.17

General Comments

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