INT250252

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.35

plasma membrane (SLC1A2, GOPC) Golgi apparatus (GOPC) cytoplasm (GOPC) transmembrane transport (SLC1A2)

Anatomy Link Frequency astrocytes 1 SLC1A2 (Homo sapiens) GOPC (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 15 99.72 Central nervous system 21 98.96 Glutamate 54 95.00 Multiple sclerosis 8 18.16 Inflammation 7 5.00 Glutamate receptor 4 5.00 excitatory amino acid 2 5.00 Demyelination 2 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 87 87.16 Demyelinating Disease 15 18.16 INFLAMMATION 8 5.00 Toxicity 5 5.00 Targeted Disruption 3 5.00 Neurodegenerative Disease 3 5.00 Autoimmune Disease 3 5.00 Pressure And Volume Under Development 2 5.00 Necrosis 1 5.00 Disease Progression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our immunohistochemical analysis of nonpathologic human CNS tissue (both cortical and spinal cord) reveal that EAAT2, but not EAAT1, normally colocalizes with AQP4 in gray matter astrocytes (Fig. 5 A) and that EAAT2 is most enriched in spinal cord gray matter (Fig. 5 B, top).

EAAT2 Binding (colocalizes) of Fig in astrocytes associated with central nervous system and spinal cord

1) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.44 Pain Relevance 0.35

General Comments

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