INT250253

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.95
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AQP4, SLC1A2) transmembrane transport (AQP4, SLC1A2) transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
plasma 1
astrocytes 1
AQP4 (Homo sapiens)
SLC1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 216 99.74 Very High Very High Very High
Spinal cord 60 99.72 Very High Very High Very High
Central nervous system 84 98.96 Very High Very High Very High
Inflammation 28 94.76 High High
Glutamate receptor 16 91.08 High High
Multiple sclerosis 32 86.96 High High
Demyelination 8 62.44 Quite High
anesthesia 4 37.68 Quite Low
excitatory amino acid 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 348 99.16 Very High Very High Very High
Disease Progression 4 96.04 Very High Very High Very High
INFLAMMATION 32 94.76 High High
Toxicity 20 94.32 High High
Demyelinating Disease 60 93.80 High High
Neurodegenerative Disease 12 92.88 High High
Pressure And Volume Under Development 8 83.08 Quite High
Autoimmune Disease 12 33.76 Quite Low
Targeted Disruption 12 29.52 Quite Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our immunohistochemical analysis of nonpathologic human CNS tissue (both cortical and spinal cord) reveal that EAAT2, but not EAAT1, normally colocalizes with AQP4 in gray matter astrocytes (Fig. 5 A) and that EAAT2 is most enriched in spinal cord gray matter (Fig. 5 B, top).
AQP4 Binding (colocalizes) of EAAT2 in astrocytes associated with central nervous system and spinal cord
1) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.43 Pain Relevance 0.34
These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.
AQP4 Binding (association) of EAAT2
2) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.08
The reduction in astrocytic glutamate transport accompanying AQP4 down-regulation after exposure to NMO-IgG further supports our suggestion that AQP4 and EAAT2 are associated functionally in the plasma membrane.


AQP4 Binding (associated) of EAAT2 in plasma associated with neuromyelitis optica and glutamate
3) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.57 Pain Relevance 0.08
However, our demonstration that the major astrocytic glutamate transporter EAAT2 exists in a macromolecular complex with the AQP4 water channel, and is down-regulated by AQP4-specific autoantibodies that are restricted to patients with the NMO-spectrum of CNS inflammatory autoimmune demyelinating disorders, has unanticipated pathogenic implications for glutamate toxicity as a central mechanism in a spectrum of disorders that are commonly mistaken for MS.
AQP4 Binding (complex) of EAAT2 associated with toxicity, neuromyelitis optica, multiple sclerosis, glutamate, inflammation, central nervous system and demyelinating disease
4) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.27 Pain Relevance 0.58

General Comments

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