INT250272

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.79
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
astrocytes 6
substantia nigra 2
plasma 2
glial cells 2
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 12 100.00 Very High Very High Very High
Dopamine 48 99.84 Very High Very High Very High
Glutamate 108 99.20 Very High Very High Very High
cerebral cortex 12 96.00 Very High Very High Very High
Inflammation 59 92.20 High High
Central nervous system 54 91.68 High High
Multiple sclerosis 98 89.60 High High
Neuritis 87 86.24 High High
Demyelination 35 85.88 High High
Neurotransmitter 12 83.04 Quite High
Disease Link Frequency Relevance Heat
Prion Diseases 36 99.96 Very High Very High Very High
Recurrence 45 99.68 Very High Very High Very High
Motor Neuron Diseases 114 99.52 Very High Very High Very High
Creutzfeldt Jakob Disease 60 99.44 Very High Very High Very High
Lewy Body Disease 18 99.40 Very High Very High Very High
Toxicity 16 99.38 Very High Very High Very High
Neuromyelitis Optica 740 99.24 Very High Very High Very High
Disease 444 99.12 Very High Very High Very High
Nerve Degeneration 6 97.64 Very High Very High Very High
Targeted Disruption 73 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Positive_regulation (increased) of Gene_expression (expression) of AQP4 associated with creutzfeldt jakob disease, lewy body disease and disease
1) Confidence 0.54 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.55 Pain Relevance 0.05
Control cells were HEK293 cells stably transfected with empty vector without human AQP4 gene.
Positive_regulation (transfected) of Neg (without) Gene_expression (transfected) of AQP4 gene
2) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0 Pain Relevance 0
JSCK transfected the HEK293 cells with human AQP4 gene and is one of the investigators who interpreted the immunofluorescence results.
Positive_regulation (transfected) of Gene_expression (transfected) of AQP4 gene
3) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0 Pain Relevance 0
A report that EAAT2 expression (Western blot and RT-PCR) is reduced in AQP4-null astrocytes (8) prompted us to evaluate glutamate toxicity as a potential outcome of IgG-induced AQP4 modulation.
Positive_regulation (induced) of Gene_expression (modulation) of AQP4 in astrocytes associated with toxicity and glutamate
4) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.89 Pain Relevance 0.62
The latter finding most likely reflects an increase in serum AQP4-IgG titres during relapse, since no evidence of intrathecally produced AQP4-IgG was found in almost all cases analysed.
Positive_regulation (increase) of Gene_expression (titres) of AQP4-IgG associated with recurrence
5) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 1.09 Pain Relevance 0.15
Thus the sensitivity of our assay using M-23 AQP4 transfected cells was 97% for NMO patients and 65% for patients with suspected NMO.
Positive_regulation (transfected) of Gene_expression (transfected) of AQP4 associated with neuromyelitis optica
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.58 Pain Relevance 0.20
Our finding that both are depleted from plasma membranes of cultured astrocytes exposed to NMO-IgG is consistent with the notion that EAAT2 expression depends on AQP4 expression.
Positive_regulation (depends) of Gene_expression (expression) of AQP4 in plasma associated with neuromyelitis optica
7) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.26 Pain Relevance 0.12
Enhanced expression of AQP4 in Creutzfeldt-Jakob disease (CJD) was first reported by IwasakiÂ’s laboratory [37].
Positive_regulation (Enhanced) of Gene_expression (expression) of AQP4 associated with creutzfeldt jakob disease and disease
8) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.51 Pain Relevance 0.07
In addition, the expression of AQP4 in the lesioned striatum needs to be investigated, considering that in the substantia nigra an increase in AQP4 mRNA following 6-hydroxidopamine (6-OH-DA) lesion has been observed [94].
Spec (investigated) Positive_regulation (increase) of Gene_expression (expression) of AQP4 in substantia nigra associated with dopamine and substantia nigra
9) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.61 Pain Relevance 0.31
Over-expression of AQP4 at the glio-vascular swollen end-feet it has been observed in the transgenic rats SOD1 [73]: these findings are in agreement with the observation that AQP4 induction in perivascular astrocytes has been correlated to BBB breakdown and could serve as a marker of BBB integrity [88].
Positive_regulation (Over) of Gene_expression (expression) of AQP4 in astrocytes associated with targeted disruption
10) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.96 Pain Relevance 0.03
The results presented by these authors show a down-regulation of AQP4 expression in striatal glial cells in vitro mediated by DA.
Positive_regulation (mediated) of Gene_expression (expression) of AQP4 in glial cells associated with dopamine
11) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.37 Pain Relevance 0.28
Over-expression of AQP4 at the glio-vascular swollen end-feet it has been observed in the transgenic rats SOD1 [73]: these findings are in agreement with the observation that AQP4 induction in perivascular astrocytes has been correlated to BBB breakdown and could serve as a marker of BBB integrity [88].
Positive_regulation (expression) of Gene_expression (expression) of AQP4 in astrocytes associated with targeted disruption
12) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.96 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox