INT250276

Context Info Confidence 0.61 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.40 Pain Relevance 0.44

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)

Anatomy Link Frequency vesicles 1 SLC1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 84 99.84 Glutamate 216 88.56 Spinal cord 60 63.12 addiction 4 33.88 Multiple sclerosis 32 5.00 Inflammation 28 5.00 Glutamate receptor 16 5.00 excitatory amino acid 8 5.00 Demyelination 8 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 348 99.52 Targeted Disruption 12 6.80 Demyelinating Disease 60 5.00 INFLAMMATION 32 5.00 Toxicity 20 5.00 Neurodegenerative Disease 12 5.00 Autoimmune Disease 12 5.00 Pressure And Volume Under Development 8 5.00 Necrosis 4 5.00 Disease Progression 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The white color that resulted when the images were merged suggested partial colocalization of AQP4 and EAAT2 in early endosomes (Fig. 4 B).

Spec (partial) Localization (colocalization) of EAAT2

1) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.74 Pain Relevance 0.06

Colocalization of AQP4 and EAAT2 in CNS tissue

Localization (Colocalization) of EAAT2 associated with central nervous system

2) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.21 Pain Relevance 0.20

Higher magnification (Fig. 4 A) revealed apparent colocalization of EAAT2 and AQP4 in early endosomal vesicles to which we previously demonstrated AQP4 translocation after exposure to NMO serum (6).

Localization (colocalization) of EAAT2 in vesicles associated with neuromyelitis optica

3) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.13

Exposure to NMO-IgG did not affect the distribution of EAAT1 or EAAT2 in AQP5-GFP cells (Fig. 4, C and E).

Localization (distribution) of EAAT2 associated with neuromyelitis optica

4) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.77 Pain Relevance 0.04

General Comments

This test has worked.