INT250278

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.52
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)
Anatomy Link Frequency
plasma 1
SLC1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 162 97.66 Very High Very High Very High
Central nervous system 63 73.20 Quite High
Spinal cord 45 36.64 Quite Low
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
Inflammation 21 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
excitatory amino acid 6 5.00 Very Low Very Low Very Low
Demyelination 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 261 98.98 Very High Very High Very High
Demyelinating Disease 45 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Autoimmune Disease 9 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.
EAAT2 Binding (association) of
1) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.08
The reduction in astrocytic glutamate transport accompanying AQP4 down-regulation after exposure to NMO-IgG further supports our suggestion that AQP4 and EAAT2 are associated functionally in the plasma membrane.


EAAT2 Binding (associated) of in plasma associated with neuromyelitis optica and glutamate
2) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.57 Pain Relevance 0.08
We obtained similar data using independent IgGs recognizing different EAAT2 epitopes (unpublished data).
EAAT2 Binding (recognizing) of
3) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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