INT250278

Context Info Confidence 0.28 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.52 Pain Relevance 0.24

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)

Anatomy Link Frequency plasma 1 SLC1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 162 97.66 Central nervous system 63 73.20 Spinal cord 45 36.64 Multiple sclerosis 24 5.00 Inflammation 21 5.00 Glutamate receptor 12 5.00 excitatory amino acid 6 5.00 Demyelination 6 5.00 anesthesia 3 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 261 98.98 Demyelinating Disease 45 5.00 INFLAMMATION 24 5.00 Toxicity 15 5.00 Targeted Disruption 9 5.00 Neurodegenerative Disease 9 5.00 Autoimmune Disease 9 5.00 Pressure And Volume Under Development 6 5.00 Necrosis 3 5.00 Disease Progression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results imply a specific association between AQP4 and EAAT2 that does not exist for EAAT1.

EAAT2 Binding (association) of

1) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.08

The reduction in astrocytic glutamate transport accompanying AQP4 down-regulation after exposure to NMO-IgG further supports our suggestion that AQP4 and EAAT2 are associated functionally in the plasma membrane.

EAAT2 Binding (associated) of in plasma associated with neuromyelitis optica and glutamate

2) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.57 Pain Relevance 0.08

We obtained similar data using independent IgGs recognizing different EAAT2 epitopes (unpublished data).

EAAT2 Binding (recognizing) of

3) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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