INT250281

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.19
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
urine 4
peritoneal macrophages 2
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 21 95.48 Very High Very High Very High
Inflammatory response 1 95.32 Very High Very High Very High
cytokine 13 85.44 High High
excitatory amino acid 2 79.84 Quite High
corticosteroid 4 73.60 Quite High
Multiple sclerosis 8 69.52 Quite High
methotrexate 2 67.76 Quite High
Glutamate 54 64.88 Quite High
Glutamate receptor 4 60.40 Quite High
fibrosis 3 57.88 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 87 99.72 Very High Very High Very High
Autoimmune Disease 3 99.22 Very High Very High Very High
Hypergammaglobulinemia 1 97.52 Very High Very High Very High
Ulcers 20 96.76 Very High Very High Very High
INFLAMMATION 18 95.32 Very High Very High Very High
Duodenal Ulcer 6 94.20 High High
Cancer 75 91.04 High High
Necrosis 2 90.56 High High
Demyelinating Disease 15 69.52 Quite High
Mouth Ulcer 14 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory test showed that more male patients than female ones were positive for increased urine protein, but female patients were more than male ones for elevated IgM and decreased C3, and C4.
Positive_regulation (positive) of Positive_regulation (elevated) of IgM in urine
1) Confidence 0.23 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768236 Disease Relevance 0.63 Pain Relevance 0.07
Laboratory test showed that more male patients than female ones were positive for increased urine protein, but female patients were more than male ones for elevated IgM and decreased C3, and C4.
Positive_regulation (decreased) of Positive_regulation (elevated) of IgM in urine
2) Confidence 0.23 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768236 Disease Relevance 0.55 Pain Relevance 0.07
Some experimental studies have investigated the effect of silicone itself or silicone mixed with complete or incomplete Freund's adjuvant.[12–15] Naim and colleagues investigated the induction of hypergammaglobulinemia and macrophage activation by silicone oil in female ASW mice, showing that intraperitoneal injection of 0.5 ml of this oil resulted in an increase in the total serum IgM and IgG.[16] Furthermore, the peritoneal macrophages of these mice produced higher levels of IL-1-?
Positive_regulation (resulted) of Positive_regulation (increase) of IgM in peritoneal macrophages associated with hypergammaglobulinemia
3) Confidence 0.06 Published 2008 Journal Journal of Carcinogenesis Section Body Doc Link PMC2669724 Disease Relevance 0.68 Pain Relevance 0.22
Multisystem autoimmune diseases frequently accompany NMO (7), and the elevated circulating IgM that is characteristic of multisystem autoimmunity has rheumatoid factor–like properties that could amplify the CNS inflammatory response in NMO (6).
Positive_regulation (elevated) of Positive_regulation (circulating) of IgM associated with neuromyelitis optica, inflammatory response, autoimmune disease and central nervous system
4) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.33 Pain Relevance 0.37

General Comments

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