INT25029

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.77
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
joint 6
hypothalamus 2
brain 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 2 98.76 Very High Very High Very High
Serotonin 1 96.76 Very High Very High Very High
noradrenaline 4 96.20 Very High Very High Very High
rheumatoid arthritis 363 96.16 Very High Very High Very High
Inflammation 130 95.84 Very High Very High Very High
Dopamine 3 95.60 Very High Very High Very High
Opioid 82 94.80 High High
metalloproteinase 63 90.92 High High
Endogenous opioid 2 90.80 High High
Anterior cingulate cortex 1 89.72 High High
Disease Link Frequency Relevance Heat
Stress 56 99.96 Very High Very High Very High
Osteoarthritis 54 99.36 Very High Very High Very High
Rheumatoid Arthritis 363 96.16 Very High Very High Very High
INFLAMMATION 127 95.84 Very High Very High Very High
Arthropathy 3 95.32 Very High Very High Very High
Severe Combined Immunodeficiency 4 87.48 High High
Cognitive Disorder 60 83.92 Quite High
Adhesions 84 74.04 Quite High
Opiate Addiction 41 72.40 Quite High
Fatigue 2 68.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes.
Positive_regulation (mediates) of Positive_regulation (Activation) of CRF in brain associated with stress
1) Confidence 0.49 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11208537 Disease Relevance 0.34 Pain Relevance 0.11
We suggest that the disruptive effect of stress on reproductive function in the women could be, at least in part, dependent on decreased gonadotropin secretion induced by elevated endogenous CRH levels.
Positive_regulation (induced) of Positive_regulation (elevated) of CRH associated with stress
2) Confidence 0.48 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0.10 Pain Relevance 0.36
Elevated levels of corticotropin-releasing hormone (CRH) are produced locally in the inflamed synovium, and a role for CRH is indicated in the pathogenesis of inflammatory joint disease [113].
Positive_regulation (Elevated) of Positive_regulation (levels) of corticotropin-releasing hormone in joint associated with inflammation and arthropathy
3) Confidence 0.38 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.31 Pain Relevance 0.61
Hobel and colleagues [53] conducted serial assessments of CRH over the course of gestation and found that compared with women delivering at term, women delivering preterm had significantly elevated CRH levels as well as a significantly accelerated rate of CRH increase over the course of their gestation.
Positive_regulation (accelerated) of Positive_regulation (increase) of CRH
4) Confidence 0.34 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.98 Pain Relevance 0.10
Elevated levels of corticotropin-releasing hormone (CRH) are produced locally in the inflamed synovium, and a role for CRH is indicated in the pathogenesis of inflammatory joint disease [113].
Positive_regulation (Elevated) of Positive_regulation (Elevated) of CRH in joint associated with inflammation and arthropathy
5) Confidence 0.28 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.31 Pain Relevance 0.61
Elevated levels of corticotropin-releasing hormone (CRH) are produced locally in the inflamed synovium, and a role for CRH is indicated in the pathogenesis of inflammatory joint disease [113].
Positive_regulation (levels) of Positive_regulation (Elevated) of corticotropin-releasing hormone in joint associated with inflammation and arthropathy
6) Confidence 0.26 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.31 Pain Relevance 0.61
Hobel and colleagues [53] conducted serial assessments of CRH over the course of gestation and found that compared with women delivering at term, women delivering preterm had significantly elevated CRH levels as well as a significantly accelerated rate of CRH increase over the course of their gestation.
Positive_regulation (accelerated) of Positive_regulation (increase) of CRH
7) Confidence 0.25 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.98 Pain Relevance 0.10
Finally, brain stress systems are activated due to noradrenergic activation of corticotrophin releasing factor from the hypothalamus and the amygdala [21] In concordance with this an elevation of cortisol secretion takes place during early opioid abstinence [22].
Positive_regulation (activated) of Positive_regulation (activation) of corticotrophin releasing factor in hypothalamus associated with stress, opioid and amygdala
8) Confidence 0.20 Published 2006 Journal BMC Psychiatry Section Body Doc Link PMC1489929 Disease Relevance 0.44 Pain Relevance 1.01

General Comments

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