INT25031

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Context Info
Confidence 0.54
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.86
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 6
tube 2
arms 2
pituitary 2
sperm 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.70 Very High Very High Very High
antagonist 18 98.92 Very High Very High Very High
narcan 25 97.36 Very High Very High Very High
opiate 5 96.72 Very High Very High Very High
headache 3 95.76 Very High Very High Very High
agonist 30 94.08 High High
Clonidine 1 92.64 High High
addiction 1 90.64 High High
Endogenous opioid 7 87.28 High High
Inflammation 6 76.08 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 6 99.98 Very High Very High Very High
Opiate Addiction 3 99.20 Very High Very High Very High
Vomiting 2 96.28 Very High Very High Very High
Stress 14 96.08 Very High Very High Very High
Headache 3 95.76 Very High Very High Very High
Polycystic Ovary Syndrome 24 94.80 High High
Lifespan 4 94.76 High High
Obesity 2 92.48 High High
Endometriosis (extended) 82 86.28 High High
Adhesions 6 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Negative_regulation (inhibition) of Gene_expression (production) of LH in pituitary
1) Confidence 0.54 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.08 Pain Relevance 0.15
Morphine significantly decreased plasma LH levels in all groups examined (P less than 0.01).
Negative_regulation (decreased) of Gene_expression (levels) of LH in plasma associated with morphine
2) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.21 Pain Relevance 0.86
LH levels after chronic heroin use were lower than control levels but the degree of LH suppression was approximately the same as after the acute doses of heroin.
Negative_regulation (degree) of Gene_expression (suppression) of LH associated with opiate addiction
3) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.28 Pain Relevance 0.38
The observation that hypoglycemia inhibited LH levels only during a period of restraint suggests either an additive or synergistic effect of these two stresses on LH secretion.
Negative_regulation (inhibited) of Gene_expression (levels) of LH associated with stress and hypoglycemia
4) Confidence 0.40 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.59 Pain Relevance 0.40
In group III, the single high dose of 1200 mg VPA significantly suppressed serum LH levels.
Negative_regulation (suppressed) of Gene_expression (levels) of LH
5) Confidence 0.37 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.27
Plasma levels of PRL, FSH and LH were unaffected by the drug.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of LH in Plasma
6) Confidence 0.30 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2901180 Disease Relevance 0 Pain Relevance 0.22
In vitro studies performed on explanted fallopian tissues showed that LH addition produces a dramatic reduction of tube motility [31].
Negative_regulation (reduction) of Gene_expression (produces) of LH in tube
7) Confidence 0.29 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.20 Pain Relevance 0
This could in turn imply that only patients highly positive for LH/hCG-R expression could receive benefits from a therapy aimed at decreasing LH levels, through Gn-RH analogues.
Negative_regulation (decreasing) of Gene_expression (levels) of LH
8) Confidence 0.29 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.47 Pain Relevance 0
CRH infusion induced a significant decrease in plasma LH and FSH levels in all women.
Negative_regulation (decrease) of Gene_expression (levels) of LH in plasma
9) Confidence 0.26 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.30
Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH.
Negative_regulation (decreased) of Gene_expression (levels) of LH
10) Confidence 0.25 Published 2003 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 12910066 Disease Relevance 1.12 Pain Relevance 0.27
Treatment of rhesus macaques with an antagonist of gonadotrophin-releasing hormone (GnRH; Antide, to inhibit LH production) results in rapid destruction of developed CL [as evidenced by a dramatic drop in progesterone (P) secretion], but the functional lifespan of these CL can be rescued by pulsatile administration of exogenous LH (Duffy et al., 1999b).
Negative_regulation (inhibit) of Gene_expression (production) of LH associated with lifespan and antagonist
11) Confidence 0.14 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2647108 Disease Relevance 0.09 Pain Relevance 0.05
In the present study we were able to show that with ovarian drilling, T and LH levels decreased irrespective of ovulation.
Negative_regulation (decreased) of Gene_expression (levels) of LH
12) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.50 Pain Relevance 0
In the degarelix groups, median LH and FSH levels decreased rapidly and remained suppressed until the end of the study, whereas LH and FSH levels showed an initial increase for patients in the leuprolide group, and FSH levels did not fall to the same extent as they did in the degarelix arms.
Negative_regulation (decreased) of Gene_expression (levels) of LH in arms
13) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0 Pain Relevance 0
In theory, an alteration in the ratios of estrogen and testosterone systemically or within the testis could decrease pituitary levels of LH and FSH and impair sperm production (Kulin and Reiter 1972; Veldhuis et al 1985).
Negative_regulation (decrease) of Gene_expression (production) of LH in sperm
14) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.32 Pain Relevance 0

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