INT25032

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.99
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 6
gland 4
plasma 2
arms 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 55 96.40 Very High Very High Very High
Dopamine 5 94.40 High High
Endogenous opioid 2 87.28 High High
antagonist 17 80.40 Quite High
anesthesia 1 79.28 Quite High
narcan 7 78.64 Quite High
Opioid 1 75.00 Quite High
endometriosis 4 73.68 Quite High
headache 3 60.40 Quite High
Spinal cord 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 23 99.02 Very High Very High Very High
Reprotox - General 1 12 83.44 Quite High
Pituitary Cancer 2 79.00 Quite High
Anxiety Disorder 5 75.00 Quite High
Affective Disorder 4 75.00 Quite High
Reprotox - General 2 10 73.68 Quite High
Galactorrhea 2 73.68 Quite High
Endometriosis (extended) 5 71.32 Quite High
Apoptosis 12 69.32 Quite High
Headache 3 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The costs per cycle of r FSH and HP FSH were compared in 2 trials and in both the cost per cycle were higher for rFSH even though in both trials a lower FSH dose could be used.31
Negative_regulation (lower) of Gene_expression (dose) of FSH
1) Confidence 0.39 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.07 Pain Relevance 0
RESULTS: One week after surgery, a GnRH-stimulation test disclosed normal basal and stimulated FSH levels and low levels of inhibin B and estradiol.
Negative_regulation (disclosed) of Gene_expression (levels) of FSH
2) Confidence 0.33 Published 2007 Journal Horm. Res. Section Body Doc Link 16974107 Disease Relevance 0.14 Pain Relevance 0
CRH infusion induced a significant decrease in plasma LH and FSH levels in all women.
Negative_regulation (decrease) of Gene_expression (levels) of FSH in plasma
3) Confidence 0.25 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.30
In the degarelix groups, median LH and FSH levels decreased rapidly and remained suppressed until the end of the study, whereas LH and FSH levels showed an initial increase for patients in the leuprolide group, and FSH levels did not fall to the same extent as they did in the degarelix arms.
Negative_regulation (decreased) of Gene_expression (levels) of FSH in arms
4) Confidence 0.08 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0 Pain Relevance 0
However, continuous administration of leuprorelin decreases levels of LH and FSH, and subsequently reduces testosterone.
Negative_regulation (decreases) of Gene_expression (levels) of FSH
5) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.14 Pain Relevance 0.03
These agents cause a reversible suppression of the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the anterior pituitary gland.
Negative_regulation (suppression) of Gene_expression (synthesis) of FSH in gland
6) Confidence 0.05 Published 1997 Journal Psychopharmacol Bull Section Abstract Doc Link 9230649 Disease Relevance 0.35 Pain Relevance 0.30
These agents cause a reversible suppression of the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the anterior pituitary gland.
Negative_regulation (suppression) of Gene_expression (synthesis) of follicle-stimulating hormone in gland
7) Confidence 0.05 Published 1997 Journal Psychopharmacol Bull Section Abstract Doc Link 9230649 Disease Relevance 0.34 Pain Relevance 0.30
In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.


Negative_regulation (inhibition) of Gene_expression (production) of follicle stimulating hormone in follicle
8) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155641 Disease Relevance 0.07 Pain Relevance 0.04
Serum concentrations of LH and FSH were remarkably suppressed in all groups (Table 1).
Negative_regulation (suppressed) of Gene_expression (concentrations) of FSH
9) Confidence 0.02 Published 2011 Journal J Ovarian Res Section Body Doc Link PMC3024996 Disease Relevance 0 Pain Relevance 0
Goserelin is a gonadotrophin-releasing hormone (GnRH) analogue which during long term administration reduces circulating levels of gonadotrophins (luteinising hormone and follicle stimulating hormone) and sex hormones.
Negative_regulation (reduces) of Gene_expression (levels) of stimulating hormone in follicle
10) Confidence 0.01 Published 1995 Journal Drugs Aging Section Abstract Doc Link 7613021 Disease Relevance 0.22 Pain Relevance 0
Compared to the controls, prolactin levels in the tumor-bearing rats had increased 70-fold, whereas the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) decreased to 20 and 27%, respectively.
Negative_regulation (decreased) of Gene_expression (levels) of FSH in follicle associated with cancer
11) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3114662 Disease Relevance 0.66 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox