INT250325

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.01
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa)
plasma membrane (Rpsa) nucleus (Rpsa) intracellular (Rpsa)
Anatomy Link Frequency
macrophages 6
myeloid cells 2
Rpsa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 96 93.76 High High
Inflammatory response 4 93.44 High High
rheumatoid arthritis 52 91.36 High High
Inflammation 16 82.32 Quite High
Demyelination 8 76.08 Quite High
chemokine 8 75.88 Quite High
cytokine 44 70.24 Quite High
Multiple sclerosis 4 70.04 Quite High
Pain 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 40 95.12 Very High Very High Very High
Arthritis 112 93.76 High High
INFLAMMATION 20 93.04 High High
Rheumatoid Arthritis 52 91.36 High High
Systemic Lupus Erythematosus 4 83.64 Quite High
Multiple Sclerosis 20 77.48 Quite High
Adhesions 4 76.40 Quite High
Demyelinating Disease 8 76.08 Quite High
Necrosis 8 75.00 Quite High
Cancer 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
has been reported to decrease p40 expression in human macrophages (18).
Negative_regulation (decrease) of Gene_expression (expression) of p40 in macrophages
1) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.43 Pain Relevance 0.32
selectively inhibits p40 expression in human and mouse myeloid cells in an IL-10–independent manner (18, 19).
Negative_regulation (inhibits) of Gene_expression (expression) of p40 in myeloid cells
2) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.68 Pain Relevance 0.28
Treatment of macrophages with rTNF also inhibited p40 production in vitro.
Negative_regulation (inhibited) of Gene_expression (production) of p40 in macrophages
3) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2571924 Disease Relevance 0.84 Pain Relevance 0.27
The maximum inhibition of p40 production by LPS-stimulated macrophages was ?
Negative_regulation (inhibition) of Gene_expression (production) of p40 in macrophages
4) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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