INT25033

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Context Info
Confidence 0.55
First Reported 1985
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.36
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 17 99.96 Very High Very High Very High
antagonist 4 99.78 Very High Very High Very High
opioid receptor 1 99.56 Very High Very High Very High
opiate 5 98.96 Very High Very High Very High
Endogenous opioid 7 97.14 Very High Very High Very High
Opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 5 100.00 Very High Very High Very High
Hypoglycemia 6 87.36 High High
Reprotox - General 1 1 46.28 Quite Low
Congenital Anomalies 1 45.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the opioid receptor antagonist naloxone, blocked the decrease of plasma LH levels.
Negative_regulation (blocked) of Negative_regulation (decrease) of LH in plasma associated with antagonist, narcan and opioid receptor
1) Confidence 0.55 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.29
A role for endogenous opioid peptides in stress-induced inhibition of LH secretion has been suggested based on the observation in rats, humans, and nonhuman primates that LH inhibition in response to a variety of different stresses could be blocked by the administration of opiate antagonists.
Negative_regulation (blocked) of Negative_regulation (inhibition) of LH associated with stress, antagonist, endogenous opioid and opiate
2) Confidence 0.40 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.36 Pain Relevance 0.51
Addition of naloxone to CRH (5 women) reversed the LH and FSH inhibition when naloxone was started 1 h after the start of the CRH infusion.
Negative_regulation (reversed) of Negative_regulation (inhibition) of LH associated with narcan
3) Confidence 0.30 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0 Pain Relevance 0.42
Addition of naloxone to CRF prevented the CRF-mediated suppression of LH and FSH release.
Negative_regulation (prevented) of Negative_regulation (suppression) of LH associated with narcan
4) Confidence 0.16 Published 1987 Journal Endocrinology Section Abstract Doc Link 3113919 Disease Relevance 0 Pain Relevance 0.38

General Comments

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