INT25036

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Context Info
Confidence 0.27
First Reported 1980
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.75
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TRH, Prl) signal transduction (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
TRH (Homo sapiens)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 11 99.84 Very High Very High Very High
Migraine 2 95.44 Very High Very High Very High
depression 2 90.56 High High
headache 3 10.00 Low Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 9 99.84 Very High Very High Very High
Dysmenorrhea 2 97.72 Very High Very High Very High
Galactorrhea 2 96.92 Very High Very High Very High
Prolactinoma 1 95.68 Very High Very High Very High
Migraine Without Aura 1 95.44 Very High Very High Very High
Hypothyroidism 2 93.60 High High
Cancer 2 92.56 High High
Depression 2 90.56 High High
Pituitary Cancer 1 75.00 Quite High
Headache 2 70.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In preoperative patients there was a blunted or absent PRL response to TRH in 87%, to MCP in 100%, to CPZ in 100%, and to ITT in 93%.
TRH Regulation (response) of PRL
1) Confidence 0.27 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6775003 Disease Relevance 0.61 Pain Relevance 0.17
The plants product induced a significant increase in Prl and TSH response to TRH.
TRH Regulation (response) of Prl
2) Confidence 0.11 Published 1998 Journal Minerva Ginecol Section Body Doc Link 9677811 Disease Relevance 0 Pain Relevance 0
Thyrotropin and prolactin responses to thyrotropin-releasing hormone in premenstrual syndrome.
thyrotropin-releasing hormone Regulation (responses) of prolactin associated with dismenorea
3) Confidence 0.05 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2493039 Disease Relevance 0.91 Pain Relevance 0.71
Basal PRL levels were not modified by the treatment, but TRH stimulated PRL values were significantly enhanced after a 30-day FLU therapy.
TRH Neg (not) Regulation (modified) of PRL
4) Confidence 0.03 Published 1988 Journal J. Neural Transm. Section Abstract Doc Link 3139830 Disease Relevance 0.24 Pain Relevance 0.20

General Comments

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