INT25043

Context Info Confidence 0.50 First Reported 1984 Last Reported 1998 Negated 1 Speculated 2 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.00 Pain Relevance 1.06

extracellular space (Crh) extracellular region (Crh) response to stress (Crh) cytoplasm (Crh)

Anatomy Link Frequency hypothalamus 6 neurosecretory neurons 2 adrenal glands 2 Crh (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 10 99.98 Neuropeptide 2 99.56 opiate 1 96.88 Intracerebroventricular 2 82.72 palliative 1 80.24 antagonist 2 75.36 Enkephalin 4 74.32 cerebral cortex 1 46.24 amygdala 1 45.56 corticosteroid 1 28.92

Disease Link Frequency Relevance Heat Stress 11 95.40 Disease 2 89.84 Pituitary Cancer 1 88.24 Syndrome 1 81.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).

Spec (investigate) Positive_regulation (mediated) of Regulation (regulation) of CRH in hypothalamus associated with stress

1) Confidence 0.50 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.29 Pain Relevance 0.08

The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).

Spec (investigate) Positive_regulation (mediated) of Regulation (regulation) of corticotropin-releasing hormone in hypothalamus associated with stress

2) Confidence 0.50 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.29 Pain Relevance 0.08

A single injection of morphine increased markedly the concentrations of ACTH in both the plasma and the adenohypophysis and the CRF content in the hypothalamus.

Positive_regulation (increased) of Regulation (concentrations) of CRF in hypothalamus associated with morphine

3) Confidence 0.44 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6325216 Disease Relevance 0.08 Pain Relevance 0.44

Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide, and steroid specificity.

Positive_regulation (enhancement) of Regulation (immunoreactivity) of CRF in neurosecretory neurons associated with neuropeptide

4) Confidence 0.42 Published 1987 Journal J. Neurosci. Section Title Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.21

Our results clearly indicate that in the primate the adrenal glands are not required for the acute CRH inhibitory effect on LH and FSH, and consequently, the decrease in gonadotropins that follows CRH is not mediated by the resultant increase in cortisol release, but, rather, by central mechanisms.

Neg (not) Positive_regulation (required) of Regulation (effect) of CRH in adrenal glands

5) Confidence 0.28 Published 1989 Journal Endocrinology Section Abstract Doc Link 2494035 Disease Relevance 0 Pain Relevance 0.17

After treatment, basal ACTH showed variable changes while the response to oCRH was markedly enhanced compared to that before ketoconazole.

Positive_regulation (enhanced) of Regulation (response) of oCRH

6) Confidence 0.22 Published 1987 Journal Horm. Metab. Res. Suppl. Section Abstract Doc Link 2832292 Disease Relevance 0.33 Pain Relevance 0.08

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