INT25043

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1984
Last Reported 1998
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.00
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 6
neurosecretory neurons 2
adrenal glands 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.98 Very High Very High Very High
Neuropeptide 2 99.56 Very High Very High Very High
opiate 1 96.88 Very High Very High Very High
Intracerebroventricular 2 82.72 Quite High
palliative 1 80.24 Quite High
antagonist 2 75.36 Quite High
Enkephalin 4 74.32 Quite High
cerebral cortex 1 46.24 Quite Low
amygdala 1 45.56 Quite Low
corticosteroid 1 28.92 Quite Low
Disease Link Frequency Relevance Heat
Stress 11 95.40 Very High Very High Very High
Disease 2 89.84 High High
Pituitary Cancer 1 88.24 High High
Syndrome 1 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).
Spec (investigate) Positive_regulation (mediated) of Regulation (regulation) of CRH in hypothalamus associated with stress
1) Confidence 0.50 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.29 Pain Relevance 0.08
The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).
Spec (investigate) Positive_regulation (mediated) of Regulation (regulation) of corticotropin-releasing hormone in hypothalamus associated with stress
2) Confidence 0.50 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.29 Pain Relevance 0.08
A single injection of morphine increased markedly the concentrations of ACTH in both the plasma and the adenohypophysis and the CRF content in the hypothalamus.
Positive_regulation (increased) of Regulation (concentrations) of CRF in hypothalamus associated with morphine
3) Confidence 0.44 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6325216 Disease Relevance 0.08 Pain Relevance 0.44
Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide, and steroid specificity.
Positive_regulation (enhancement) of Regulation (immunoreactivity) of CRF in neurosecretory neurons associated with neuropeptide
4) Confidence 0.42 Published 1987 Journal J. Neurosci. Section Title Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.21
Our results clearly indicate that in the primate the adrenal glands are not required for the acute CRH inhibitory effect on LH and FSH, and consequently, the decrease in gonadotropins that follows CRH is not mediated by the resultant increase in cortisol release, but, rather, by central mechanisms.
Neg (not) Positive_regulation (required) of Regulation (effect) of CRH in adrenal glands
5) Confidence 0.28 Published 1989 Journal Endocrinology Section Abstract Doc Link 2494035 Disease Relevance 0 Pain Relevance 0.17
After treatment, basal ACTH showed variable changes while the response to oCRH was markedly enhanced compared to that before ketoconazole.
Positive_regulation (enhanced) of Regulation (response) of oCRH
6) Confidence 0.22 Published 1987 Journal Horm. Metab. Res. Suppl. Section Abstract Doc Link 2832292 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox