INT250444

Context Info Confidence 0.00 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.42 Pain Relevance 0.86

molecular_function (Gm318) cellular_component (Gm318) biological_process (Gm318)

Gm318 (Mus musculus)

Pain Link Frequency Relevance Heat allodynia 12 89.72 nMDA receptor 145 85.80 Pain 8 81.20 Hyperalgesia 5 80.16 antagonist 34 57.04 Dorsal horn 23 53.20 substance P 11 50.00 Spinal cord 20 28.00 Glutamate 10 7.48 GABAergic 14 5.20

Disease Link Frequency Relevance Heat Neuropathic Pain 13 89.72 Pain 13 81.20 Hyperalgesia 5 80.16 Targeted Disruption 6 5.00 Hypersensitivity 4 5.00 Disseminated Intravascular Coagulation 4 5.00 Nervous System Injury 3 5.00 Injury 3 5.00 Death 2 5.00 Drug Induced Neurotoxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Figure 3C and 3D, the individual and mean values of g(-90 mV)/g(MIC) ratio and VMIC became NR2C/D type after co-application of EAB-318 and NMDA.

Gene_expression (type) of EAB-318

1) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.31

EJK provided the essential compounds UBP141 and EAB318.

Gene_expression (provided) of EAB318

2) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0.42 Pain Relevance 0.55

General Comments

This test has worked.