INT250445

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2c) plasma membrane (Grin2c) cytoplasm (Grin2c)
Anatomy Link Frequency
neurons 1
interneurons 1
Grin2c (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 59 99.80 Very High Very High Very High
Dorsal horn neuron 15 99.48 Very High Very High Very High
ketamine 75 94.08 High High
Dorsal horn 23 92.88 High High
Hippocampus 13 92.12 High High
Spinal cord 20 90.80 High High
nMDA receptor 147 89.16 High High
opioid receptor 1 84.40 Quite High
anesthesia 11 76.24 Quite High
Limbic system 4 71.68 Quite High
Disease Link Frequency Relevance Heat
Hallucination 3 55.60 Quite High
Confusion 1 52.12 Quite High
Unconsciousness 14 50.00 Quite Low
Sleep Disorders 1 49.84 Quite Low
Delirium 1 41.80 Quite Low
Psychosis 2 40.48 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
Neuropathic Pain 13 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, NR2A and NR2B mRNA are expressed mainly in pyramidal cells, whereas NR2C and NR2D mRNA are present in different subsets of hippocampal interneurons [27]–[30].
Transcription (present) of NR2C in interneurons associated with pyramidal cell
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.11 Pain Relevance 0.74
Earlier studies suggest that NR2D mRNA is expressed by many and NR2C mRNA by few dorsal horn neurons [34].
Transcription (expressed) of NR2C in neurons associated with dorsal horn neuron
2) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.44
However, based on the absence of NR2C mRNA detection as mentioned above, it is likely that NR2D is the main contributor when our data showed high conductance ratio or EAB-318 insensitivity.
Neg (absence) Transcription (absence) of NR2C
3) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.12

General Comments

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