INT250447

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 66 99.76 Very High Very High Very High
imagery 6 98.80 Very High Very High Very High
Dorsal horn neuron 12 64.24 Quite High
agonist 5 62.08 Quite High
antagonist 18 51.68 Quite High
substance P 11 50.00 Quite Low
Potency 4 27.28 Quite Low
addiction 1 25.52 Quite Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Dorsal horn 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 70.04 Quite High
Starvation 6 54.16 Quite High
Disease 15 52.80 Quite High
Apoptosis 5 51.88 Quite High
Dna Damage 1 35.44 Quite Low
Cancer 4 31.00 Quite Low
Alzheimer's Dementia 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Parkinson's Disease 9 5.00 Very Low Very Low Very Low
Toxicity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NM also induces paradoxical entry of Ca2+
Positive_regulation (induces) of Ca2 Binding (entry) of
1) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.05
In 9 of 15 cells recorded, intracellular solution containing 40 mM BAPTA was used to fully suppress accumulation of intracellular Ca2+ associated with NMDA receptor activation.
Positive_regulation (accumulation) of Ca2 Binding (associated) of associated with nmda receptor
2) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.34
Increased intracytosolic Ca2+ blocks autophagy by activating calpains (a family of Ca2+-dependent cysteine proteases), which mediate their effects on autophagy through Gs?
Positive_regulation (Increased) of Ca2 Binding (autophagy) of
3) Confidence 0.03 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.36 Pain Relevance 0

General Comments

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