INT25047

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Context Info
Confidence 0.31
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
adrenal glands 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 3 98.48 Very High Very High Very High
Morphine 3 92.28 High High
imagery 1 83.84 Quite High
Endogenous opioid 1 42.96 Quite Low
transdermal 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 76 97.96 Very High Very High Very High
Prolactinoma 1 90.16 High High
Iron Overload 1 87.68 High High
Klinefelter Syndrome 2 62.08 Quite High
Obesity 18 13.68 Low Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low
Metabolic Syndrome 22 5.00 Very Low Very Low Very Low
Reprotox - General 1 19 5.00 Very Low Very Low Very Low
Osteoporosis 12 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repeated administration of GnRH restored the hyporesponsiveness of serum FSH and increased serum testosterone level from less than 1.0 to 1.7 nmol/l, but the impaired LH response to the standard GnRH test was not improved.
Positive_regulation (restored) of Regulation (hyporesponsiveness) of FSH
1) Confidence 0.31 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.16 Pain Relevance 0.08
Unless fertility is an issue, it is usually not necessary to measure FSH and determining LH levels alone is sufficient.
Neg (not) Positive_regulation (necessary) of Regulation (measure) of FSH
2) Confidence 0.16 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.77 Pain Relevance 0.04
Our results clearly indicate that in the primate the adrenal glands are not required for the acute CRH inhibitory effect on LH and FSH, and consequently, the decrease in gonadotropins that follows CRH is not mediated by the resultant increase in cortisol release, but, rather, by central mechanisms.
Neg (not) Positive_regulation (required) of Regulation (effect) of FSH in adrenal glands
3) Confidence 0.14 Published 1989 Journal Endocrinology Section Abstract Doc Link 2494035 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

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