INT250515

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
nervous system 2
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 14 85.76 High High
cerebral cortex 3 55.08 Quite High
Somatostatin 17 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 33 99.56 Very High Very High Very High
Aging 15 96.26 Very High Very High Very High
Body Weight 34 88.04 High High
Fatty Liver 2 86.72 High High
Hyperglycemia 5 84.08 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 83.36 Quite High
Targeted Disruption 9 79.68 Quite High
Obesity 34 78.96 Quite High
Microcephaly 1 25.96 Quite Low
Stress 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Regulation (response) of Gene_expression (expression) of UCP2 mRNA
1) Confidence 0.39 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Regulation (Effects) of Gene_expression (expression) of UCP2 mRNA
2) Confidence 0.39 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
Up-regulation of UCP-2 expression or overactivity of UCP-2 leads to inhibition of ATP synthesis and alteration in levels of ROS generation.
Regulation (regulation) of Gene_expression (expression) of UCP-2
3) Confidence 0.10 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.08 Pain Relevance 0
Similar patterns of survival have been described in other aging models: in Caenorhabditis elegans, ablation of ASI sensory neurons that modulate DAF-2 pathways in response to environment, increased mean, but not maximum lifespan [27]; in Drosophila, targeted expression of human uncoupling protein 2 in adult neurons [42], or inhibition of p53 specifically in the nervous system [43], extended mean, but not maximum, lifespan.
Regulation (targeted) of Gene_expression (expression) of uncoupling protein 2 in nervous system associated with aging and lifespan
4) Confidence 0.02 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.78 Pain Relevance 0

General Comments

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