INT250519

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.70
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r) kinase activity (Igf1r)
Anatomy Link Frequency
embryonic brain 1
brain 1
Igf1r (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1 91.20 High High
Inflammation 17 89.52 High High
Central nervous system 14 35.28 Quite Low
Somatostatin 34 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.24 Very High Very High Very High
Lifespan 66 99.04 Very High Very High Very High
Gastrointestinal Stromal Tumor 67 99.02 Very High Very High Very High
Cancer 75 95.24 Very High Very High Very High
Age-related Macular Degeneration 9 91.00 High High
INFLAMMATION 18 89.52 High High
Disease 28 86.92 High High
Myopia 1 86.00 High High
Death 11 84.56 Quite High
Apoptosis 3 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Partial inactivation of IGF-1R in the embryonic brain selectively inhibited GH and IGF-I pathways after birth.
Negative_regulation (inactivation) of IGF-1R in embryonic brain
1) Confidence 0.42 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2573928 Disease Relevance 0.38 Pain Relevance 0
In contrast, complete absence of brain IGF-1R in the homozygous knockout produced a very different phenotype leading to increased IGF-I; thus, the phenotype is strongly dependent on IGF-1R gene dose.
Negative_regulation (absence) of IGF-1R in brain associated with targeted disruption
2) Confidence 0.42 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.72 Pain Relevance 0
More importantly, it has been shown, by a recent study that imatinib-sensitive and -resistant GIST cells respond equally well to a small molecular inhibitor of IGF1R, suggesting an alternative and/or complementary therapeutic regimen in the clinical management of GIST, especially in tumors that respond less favorably to imatinib-based therapy, including pediatric cases.
Negative_regulation (inhibitor) of IGF1R associated with cancer and gastrointestinal stromal tumor
3) Confidence 0.29 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.64 Pain Relevance 0
Accordingly, IGF-1R inhibitors may be useful tools in the treatment of conditions associated with neovascularization.
Negative_regulation (inhibitors) of IGF-1R
4) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.95 Pain Relevance 0.09
A recent study (33) has identified several IGF-1R (insulin-like growth factor-1 receptor) tyrosine kinase inhibitors.
Negative_regulation (inhibitors) of IGF-1R
5) Confidence 0.01 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2703967 Disease Relevance 0 Pain Relevance 0

General Comments

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