INT250545

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.94
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) embryo development (Hmgcr)
Anatomy Link Frequency
colon 1
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 88.40 High High
headache 1 76.40 Quite High
abdominal pain 1 74.72 Quite High
Arthritis 1 73.44 Quite High
cINOD 14 5.00 Very Low Very Low Very Low
COX-2 inhibitor 12 5.00 Very Low Very Low Very Low
amygdala 9 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
noradrenaline 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyps 6 99.46 Very High Very High Very High
Aberrant Crypt Foci 4 99.24 Very High Very High Very High
Myocardial Infarction 46 98.20 Very High Very High Very High
Colon Cancer 66 97.64 Very High Very High Very High
Mevalonate Kinase Deficiency 58 97.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 94.24 High High
Cancer 112 93.88 High High
Breast Cancer 6 93.88 High High
Hypergammaglobulinemia 1 88.56 High High
INFLAMMATION 38 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colon cancer, the formation and progression of precancerous lesions like aberrant crypt foci and polyps is associated with the up-regulation of cycloxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and hydroxy methyl glutaryl CoA reductase (HMG-CoA reductase).
Regulation (regulation) of HMG-CoA reductase in colon associated with aberrant crypt foci, colon cancer and polyps
1) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2745153 Disease Relevance 0.99 Pain Relevance 0
The current review will focus on the upregulation of COX-2 and HMG-CoA reductase enzymes and the signaling cascades that are altered as a result of this up-regulation.
Regulation (regulation) of HMG-CoA reductase
2) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 1.37 Pain Relevance 0.04
MKD is due to mutations in the MVK gene, resulting in decreased activities of mevalonate kinase (MK; EC 2.7.1.36), the first enzyme following the highly regulated 3-hydroxy-3-methylgluaryl (HMG-CoA reductase) in the isoprenoid biosynthesis pathway (Houten et al 2003a; Waterham 2006).
Regulation (regulated) of HMG-CoA reductase associated with mevalonate kinase deficiency
3) Confidence 0.08 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.30 Pain Relevance 0.19
In this case, there is a segregation of the red and blue points suggesting that there is enough information contained in the two principal components to be able to differentiate between the reinforced and unreinforced odors.
Regulation (segregation) of red
4) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573932 Disease Relevance 0 Pain Relevance 0
Moderate Red Wine Intake Improves Cardiac Function After MI
Regulation (Moderate) of Red associated with myocardial infarction
5) Confidence 0.02 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801857 Disease Relevance 1.28 Pain Relevance 0

General Comments

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