INT250550

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.26
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CHDH) peptidase activity (F12) extracellular space (F12)
extracellular region (F12) plasma membrane (F12)
F12 (Homo sapiens)
CHDH (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 6 85.40 High High
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 144 100.00 Very High Very High Very High
Cardiovascular Disease 210 99.84 Very High Very High Very High
Stroke 99 96.32 Very High Very High Very High
Cv General 3 Under Development 6 85.40 High High
Myocardial Infarction 6 84.28 Quite High
Hypertension 6 41.28 Quite Low
Obesity 24 40.56 Quite Low
Diabetes Mellitus 3 40.36 Quite Low
Disorder Of Lipid Metabolism 48 39.04 Quite Low
Nicotine Addiction 6 36.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of haplotype effects was done for two variants of the F12 gene that were not in very high LD with each other and were both associated at p<0.01 with CHD and CVD.
F12 Binding (associated) of CHD associated with coronary artery disease and cardiovascular disease
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.62 Pain Relevance 0.17
Haplotype analysis for the two F12 variants, rs4976691 and rs1801020, in which carriers of the specific ‘risk’ haplotypes (CA, CG, or GA for rs4976691 and rs1801020, respectively) were compared to individuals homozygous for the non-risk haplotype GG did not reveal stronger association with CHD or CVD than analysis of single variants.
F12 Neg (not) Binding (association) of CHD associated with coronary artery disease and cardiovascular disease
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.86 Pain Relevance 0
The most consistent result was for CHD association with the F12 variant rs1801020 (men and women combined, p?
F12 Binding (association) of CHD associated with coronary artery disease
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.78 Pain Relevance 0

General Comments

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