INT250570

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.85
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS)
cytoplasm (SELS)
Anatomy Link Frequency
hepatocytes 2
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 81.04 Quite High
Inflammation 13 52.08 Quite High
Angina 10 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 37 99.86 Very High Very High Very High
Insulin Resistance 12 98.72 Very High Very High Very High
Cardiovascular Disease 80 97.56 Very High Very High Very High
Coronary Artery Disease 58 97.28 Very High Very High Very High
Diabetes Mellitus 43 95.96 Very High Very High Very High
Hepatocellular Cancer 4 95.32 Very High Very High Very High
Obesity 150 90.40 High High
Stress 2 81.72 Quite High
Disorder Of Lipid Metabolism 40 74.68 Quite High
Metabolic Disorder 8 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has also been shown that SELS expression is inhibited by glucose in cultured hepatocytes and that overexpression of SELS causes a reduction in glucose uptake in cultured hepatoma cells [1,6].
Negative_regulation (inhibited) of Gene_expression (expression) of SELS in hepatocytes associated with hepatocellular cancer
1) Confidence 0.43 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.02 Pain Relevance 0
In HepG2 cells, SELS expression is inhibited by glucose; and SELS has been suggested to be involved in glucose homeostasis in an animal model of type 2 diabetes mellitus [6] and in human diabetic subjects [5].
Negative_regulation (inhibited) of Gene_expression (expression) of SELS associated with diabetes mellitus
2) Confidence 0.38 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.02 Pain Relevance 0.10
For ischemic stroke, only one SEPS1 variant, rs7178239, was associated at p?
Negative_regulation (one) of Gene_expression (variant) of SEPS1 associated with stroke
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.81 Pain Relevance 0

General Comments

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