INT250581

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2011
Negated 0
Speculated 7
Reported most in Body
Documents 4
Total Number 51
Disease Relevance 47.37
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS)
cytoplasm (SELS)
Anatomy Link Frequency
adipose tissue 9
subcutaneous adipose tissue 8
adipocytes 7
liver 4
hepatocytes 2
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 194 98.72 Very High Very High Very High
cytokine 200 97.56 Very High Very High Very High
Inflammatory marker 144 97.00 Very High Very High Very High
Inflammation 300 96.32 Very High Very High Very High
rheumatoid arthritis 48 59.72 Quite High
spastic colon 1 7.44 Low Low
adenocard 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 3417 100.00 Very High Very High Very High
Stroke 129 99.78 Very High Very High Very High
Diabetes Mellitus 1014 99.68 Very High Very High Very High
Stress 62 99.52 Very High Very High Very High
Insulin Resistance 291 99.32 Very High Very High Very High
Disorder Of Lipid Metabolism 592 99.20 Very High Very High Very High
Cardiovascular Disease 311 98.84 Very High Very High Very High
Cv General 3 Under Development 194 98.72 Very High Very High Very High
Hepatocellular Cancer 96 98.00 Very High Very High Very High
Myocardial Infarction 98 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In lean subjects, we found correlations between SELS gene expression in subcutaneous adipose tissue and measures of obesity (waist, P = .045; sagittal diameter, P = .031) and blood pressure (diastolic, P = .016; systolic P = .015); and in obese subjects, we found correlations with measures of obesity (body mass index, P = .03; sagittal diameter, P = .008) and glycemic control (homeostasis model assessment of insulin resistance, P = .011; insulin, P = .009) after adjusting for age and sex.
Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity and insulin resistance
1) Confidence 0.78 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.66 Pain Relevance 0.28
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors

The selenoprotein S (SELS) is a putative receptor for serum amyloid A, and recent studies have suggested that SELS may be a link between type 2 diabetes mellitus and inflammation.

Gene_expression (Expression) of SELS in subcutaneous adipose tissue associated with inflammation, diabetes mellitus, alzheimer's dementia and obesity
2) Confidence 0.78 Published 2011 Journal Metabolism Section Title Doc Link PMC3004038 Disease Relevance 1.08 Pain Relevance 0.25
In the lean subjects, we found significant correlations between SELS gene expression in subcutaneous adipose tissue and waist circumference, sagittal diameter, FFM, as well as systolic and diastolic BP after adjusting for age and sex (Table 2).
Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity
3) Confidence 0.78 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.79 Pain Relevance 0
SelS expression is positively regulated by NF-?
Gene_expression (expression) of SelS
4) Confidence 0.75 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.87 Pain Relevance 0.17
In this study, we analyzed SELS expression in subcutaneous adipose tissue and SELS genotype in relation to metabolic risk factors.
Spec (analyzed) Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity
5) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.10 Pain Relevance 0.27
Real-time polymerase chain reaction was used to analyze the SELS expression in isolated human adipocytes incubated with insulin.
Spec (analyze) Gene_expression (expression) of SELS in adipocytes associated with obesity
6) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.57 Pain Relevance 0.30
In this study, we wanted to also include measures of glycemic control, lipid metabolism, and other risk factors as well as investigate possible associations with adipose tissue expression of SELS to further explore the role of SELS and the association with metabolic disease.


Spec (investigate) Gene_expression (expression) of SELS in adipose tissue associated with metabolic disorder and obesity
7) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.09 Pain Relevance 0.10
In the SOS Sib Pair study, correlation between SELS expression, SAA expression, and anthropometric and biochemical markers was performed using the Spearman rank correlation test.
Gene_expression (expression) of SELS
8) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.38 Pain Relevance 0
DNA microarray expression analysis was used to study the expression of SELS in lean and obese siblings from the Swedish Obese Subjects Sib Pair Study.
Gene_expression (expression) of SELS associated with obesity
9) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.18 Pain Relevance 0.29
SELS expression was analyzed using probe set 223209_s_at, and SAA expression was analyzed using probe set 214456_x_at.


Spec (analyzed) Gene_expression (expression) of SELS
10) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.17 Pain Relevance 0
SELS expression in insulin-stimulated adipocytes
Gene_expression (expression) of SELS in adipocytes associated with obesity
11) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.87 Pain Relevance 0
In this study, we analyzed SELS expression in subcutaneous adipose tissue and SELS genotype in relation to metabolic risk factors.
Spec (analyzed) Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity
12) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.08 Pain Relevance 0.26
The expression of SELS increased after insulin stimulation in isolated human adipocytes (P = .008).
Gene_expression (expression) of SELS in adipocytes associated with obesity
13) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.30 Pain Relevance 0.16
To further investigate the link between glycemic control and SELS gene expression, we analyzed the effect of insulin stimulation on isolated subcutaneous adipocytes and found that the expression of SELS increased after insulin stimulation (Fig. 1, P = .008).
Gene_expression (expression) of SELS in adipocytes associated with obesity
14) Confidence 0.67 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.86 Pain Relevance 0
The activation of SELS expression is influenced by a promoter polymorphism (rs28665122); and human studies have shown that SELS genotype is associated with circulating levels of proinflammatory cytokines, such as tumor necrosis factor–?
Gene_expression (expression) of SELS associated with necrosis, cancer and cytokine
15) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.05 Pain Relevance 0.13
It has also been shown that SELS expression is inhibited by glucose in cultured hepatocytes and that overexpression of SELS causes a reduction in glucose uptake in cultured hepatoma cells [1,6].
Gene_expression (overexpression) of SELS in hepatocytes associated with hepatocellular cancer
16) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.07 Pain Relevance 0
Differences in gene expression between lean and obese siblings as well as SELS gene expression in isolated adipocytes incubated with or without insulin were assessed using a paired t test.
Gene_expression (expression) of SELS in adipocytes associated with obesity
17) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.28 Pain Relevance 0
Furthermore, SELS gene expression was associated with measures of glycemic control and serum levels of HDL cholesterol in obese subjects, whereas SELS gene expression and BP were associated in lean subjects.
Gene_expression (expression) of SELS associated with obesity and disorder of lipid metabolism
18) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.70 Pain Relevance 0
Although there was a weak correlation in the obese sibling group, the correlation was lost after adjusting for sex and age and was not present in the lean group, suggesting that SELS and SAA gene expression levels are not closely related in subcutaneous adipose tissue in humans.
Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity
19) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.49 Pain Relevance 0.12
We have also shown that SELS gene expression is stimulated by insulin in isolated human adipocytes.
Gene_expression (expression) of SELS in adipocytes associated with obesity
20) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.84 Pain Relevance 0

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