INT250581

Context Info Confidence 0.78 First Reported 2008 Last Reported 2011 Negated 0 Speculated 7 Reported most in Body Documents 4 Total Number 51 Disease Relevance 47.37 Pain Relevance 3.27

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS) cytoplasm (SELS)

Anatomy Link Frequency adipose tissue 9 subcutaneous adipose tissue 8 adipocytes 7 liver 4 hepatocytes 2 SELS (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 194 98.72 cytokine 200 97.56 Inflammatory marker 144 97.00 Inflammation 300 96.32 rheumatoid arthritis 48 59.72 spastic colon 1 7.44 adenocard 2 5.00 COX2 1 5.00 Central nervous system 1 5.00 member 8 1 5.00

Disease Link Frequency Relevance Heat Obesity 3417 100.00 Stroke 129 99.78 Diabetes Mellitus 1014 99.68 Stress 62 99.52 Insulin Resistance 291 99.32 Disorder Of Lipid Metabolism 592 99.20 Cardiovascular Disease 311 98.84 Cv General 3 Under Development 194 98.72 Hepatocellular Cancer 96 98.00 Myocardial Infarction 98 97.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In lean subjects, we found correlations between SELS gene expression in subcutaneous adipose tissue and measures of obesity (waist, P = .045; sagittal diameter, P = .031) and blood pressure (diastolic, P = .016; systolic P = .015); and in obese subjects, we found correlations with measures of obesity (body mass index, P = .03; sagittal diameter, P = .008) and glycemic control (homeostasis model assessment of insulin resistance, P = .011; insulin, P = .009) after adjusting for age and sex.

Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity and insulin resistance

1) Confidence 0.78 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.66 Pain Relevance 0.28

Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors The selenoprotein S (SELS) is a putative receptor for serum amyloid A, and recent studies have suggested that SELS may be a link between type 2 diabetes mellitus and inflammation.

Gene_expression (Expression) of SELS in subcutaneous adipose tissue associated with inflammation, diabetes mellitus, alzheimer's dementia and obesity

2) Confidence 0.78 Published 2011 Journal Metabolism Section Title Doc Link PMC3004038 Disease Relevance 1.08 Pain Relevance 0.25

In the lean subjects, we found significant correlations between SELS gene expression in subcutaneous adipose tissue and waist circumference, sagittal diameter, FFM, as well as systolic and diastolic BP after adjusting for age and sex (Table 2).

Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity

3) Confidence 0.78 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.79 Pain Relevance 0

SelS expression is positively regulated by NF-?

Gene_expression (expression) of SelS

4) Confidence 0.75 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.87 Pain Relevance 0.17

In this study, we analyzed SELS expression in subcutaneous adipose tissue and SELS genotype in relation to metabolic risk factors.

Spec (analyzed) Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity

5) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.10 Pain Relevance 0.27

Real-time polymerase chain reaction was used to analyze the SELS expression in isolated human adipocytes incubated with insulin.

Spec (analyze) Gene_expression (expression) of SELS in adipocytes associated with obesity

6) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.57 Pain Relevance 0.30

In this study, we wanted to also include measures of glycemic control, lipid metabolism, and other risk factors as well as investigate possible associations with adipose tissue expression of SELS to further explore the role of SELS and the association with metabolic disease.

Spec (investigate) Gene_expression (expression) of SELS in adipose tissue associated with metabolic disorder and obesity

7) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.09 Pain Relevance 0.10

In the SOS Sib Pair study, correlation between SELS expression, SAA expression, and anthropometric and biochemical markers was performed using the Spearman rank correlation test.

Gene_expression (expression) of SELS

8) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.38 Pain Relevance 0

DNA microarray expression analysis was used to study the expression of SELS in lean and obese siblings from the Swedish Obese Subjects Sib Pair Study.

Gene_expression (expression) of SELS associated with obesity

9) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.18 Pain Relevance 0.29

SELS expression was analyzed using probe set 223209_s_at, and SAA expression was analyzed using probe set 214456_x_at.

Spec (analyzed) Gene_expression (expression) of SELS

10) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.17 Pain Relevance 0

SELS expression in insulin-stimulated adipocytes

Gene_expression (expression) of SELS in adipocytes associated with obesity

11) Confidence 0.68 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.87 Pain Relevance 0

In this study, we analyzed SELS expression in subcutaneous adipose tissue and SELS genotype in relation to metabolic risk factors.

Spec (analyzed) Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity

12) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.08 Pain Relevance 0.26

The expression of SELS increased after insulin stimulation in isolated human adipocytes (P = .008).

Gene_expression (expression) of SELS in adipocytes associated with obesity

13) Confidence 0.68 Published 2011 Journal Metabolism Section Abstract Doc Link PMC3004038 Disease Relevance 1.30 Pain Relevance 0.16

To further investigate the link between glycemic control and SELS gene expression, we analyzed the effect of insulin stimulation on isolated subcutaneous adipocytes and found that the expression of SELS increased after insulin stimulation (Fig. 1, P = .008).

Gene_expression (expression) of SELS in adipocytes associated with obesity

14) Confidence 0.67 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.86 Pain Relevance 0

The activation of SELS expression is influenced by a promoter polymorphism (rs28665122); and human studies have shown that SELS genotype is associated with circulating levels of proinflammatory cytokines, such as tumor necrosis factor–?

Gene_expression (expression) of SELS associated with necrosis, cancer and cytokine

15) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.05 Pain Relevance 0.13

It has also been shown that SELS expression is inhibited by glucose in cultured hepatocytes and that overexpression of SELS causes a reduction in glucose uptake in cultured hepatoma cells [1,6].

Gene_expression (overexpression) of SELS in hepatocytes associated with hepatocellular cancer

16) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.07 Pain Relevance 0

Differences in gene expression between lean and obese siblings as well as SELS gene expression in isolated adipocytes incubated with or without insulin were assessed using a paired t test.

Gene_expression (expression) of SELS in adipocytes associated with obesity

17) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.28 Pain Relevance 0

Furthermore, SELS gene expression was associated with measures of glycemic control and serum levels of HDL cholesterol in obese subjects, whereas SELS gene expression and BP were associated in lean subjects.

Gene_expression (expression) of SELS associated with obesity and disorder of lipid metabolism

18) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.70 Pain Relevance 0

Although there was a weak correlation in the obese sibling group, the correlation was lost after adjusting for sex and age and was not present in the lean group, suggesting that SELS and SAA gene expression levels are not closely related in subcutaneous adipose tissue in humans.

Gene_expression (expression) of SELS in subcutaneous adipose tissue associated with obesity

19) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.49 Pain Relevance 0.12

We have also shown that SELS gene expression is stimulated by insulin in isolated human adipocytes.

Gene_expression (expression) of SELS in adipocytes associated with obesity

20) Confidence 0.60 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.84 Pain Relevance 0

General Comments

This test has worked.