INT250588

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) RNA binding (MCTS1)
plasma membrane (BSG) cell cycle (MCTS1) cytoplasm (MCTS1)
Anatomy Link Frequency
plasma 1
BSG (Homo sapiens)
MCTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 20 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
narcan 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 87.72 High High
Apoptosis 4 87.28 High High
Glioma 4 84.64 Quite High
Neuroblastoma 8 84.20 Quite High
Skin Cancer 4 79.96 Quite High
Overdose 28 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Respiratory Failure 4 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Coma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Topology studies suggest that one MCT1 molecule interacts with a single CD147 molecule with subsequent dimerization with another MCT1/CD147 pair.(49).
CD147 Binding (interacts) of MCT1
1) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.45 Pain Relevance 0
The initial association of CD147 and MCT1 is required for the translocation of MCT1 to the plasma membrane (48).
CD147 Binding (association) of MCT1 in plasma
2) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.42 Pain Relevance 0
Topology studies suggest that one MCT1 molecule interacts with a single CD147 molecule with subsequent dimerization with another MCT1/CD147 pair.(49).
CD147 Binding (interacts) of MCT1
3) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.45 Pain Relevance 0
MCT1 is further regulated by its association with the cell surface glycoprotein CD147, which has a single transmembrane domain with the C-terminus located in the cytosol (48,49).
CD147 Binding (association) of MCT1
4) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.50 Pain Relevance 0

General Comments

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