INT250599

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 1.40
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (MCTS1) cell cycle (MCTS1) cytoplasm (MCTS1)
Anatomy Link Frequency
kidney 5
Caco-2 4
liver 2
brain 2
intestine 2
MCTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 304 99.92 Very High Very High Very High
Bioavailability 107 90.80 High High
Potency 56 67.16 Quite High
agonist 31 65.44 Quite High
narcan 28 49.28 Quite Low
depression 28 38.08 Quite Low
Central nervous system 28 37.00 Quite Low
withdrawal 29 18.44 Low Low
alcohol 28 18.00 Low Low
Glutamate receptor 28 13.76 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 56 98.32 Very High Very High Very High
Skin Cancer 28 97.60 Very High Very High Very High
Glioma 28 85.68 High High
Breast Cancer 28 82.56 Quite High
Apoptosis 28 80.64 Quite High
Death 56 79.44 Quite High
Metastasis 28 75.60 Quite High
Overdose 196 71.36 Quite High
Disease 29 69.16 Quite High
Increased Venous Pressure Under Development 28 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, treatment with testosterone resulted in increased skeletal muscle MCT1 protein expression and lactate transport in the absence of mRNA changes suggesting the importance of post-transcriptional regulation (27).
Gene_expression (expression) of MCT1 in skeletal muscle
1) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.11 Pain Relevance 0
Protein expression of MCT1, MCT2 and MCT4 has been demonstrated in human intestinal Caco-2 cells (unpublished data).
Gene_expression (expression) of MCT1 in Caco-2
2) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.03
Caco-2 cells have been demonstrated to express MCT1, 2 and 4 protein (unpublished data from our lab) with MCT1 expression being the predominant form consistent with expression in the human intestine (19).
Gene_expression (express) of MCT1 in Caco-2
3) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
In addition, increased MCT1 expression and activity have been reported in human neuroblastoma and melanoma cell lines resulting from low extracellular pH (41,45).
Gene_expression (expression) of MCT1 associated with neuroblastoma and skin cancer
4) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.53 Pain Relevance 0
Uptake of butyrate by intestinal epithelia cells is highly dependent on MCT1 expression; alterations in MCT1 levels results in altered uptake of butyrate which is the primary energy source for these cells (36,37).
Gene_expression (expression) of MCT1
5) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.21
MCT1 is expressed at both membranes, although there is greater expression at the BLM; MCT2 is expressed only at the BLM (12).
Gene_expression (expressed) of MCT1
6) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.06 Pain Relevance 0
MCT1 expression undergoes transcriptional, post-transcriptional and post-translational regulation and appears to be regulated in a tissue-specific manner (26–28).
Gene_expression (expression) of MCT1
7) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.14
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (express) of MCT1 in HK-2
8) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
MCT1 is expressed on brush border (apical) membrane of intestinal cells and thereby facilitates the intestinal cell uptake of its substrates.
Gene_expression (expressed) of MCT1 in intestinal cells
9) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Caco-2 cells have been demonstrated to express MCT1, 2 and 4 protein (unpublished data from our lab) with MCT1 expression being the predominant form consistent with expression in the human intestine (19).
Gene_expression (expression) of MCT1 in Caco-2
10) Confidence 0.64 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Furthermore, GHB uptake was inhibited by known MCT inhibitors including lactate and pyruvate, suggesting that GHB is a substrate for MCTs expressed at the blood–brain barrier (5).


Gene_expression (expressed) of MCTs in blood
11) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
However, based on the expression patterns of MCTs in the kidney, MCT1 is likely the primary isoform responsible for GHB renal uptake.
Gene_expression (expression) of MCTs in kidney
12) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
MCTs are expressed in a wide range of tissues, including the liver, kidney, intestine and brain (4).
Gene_expression (expressed) of MCTs in brain
13) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.06
Uptake of XP13512 was demonstrated to be MCT1-mediated in Caco-2, HEK-derived and MDCK cell monolayers (38).
Gene_expression (Uptake) of MCT1 in MDCK
14) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.32
However, based on the expression patterns of MCTs in the kidney, MCT1 is likely the primary isoform responsible for GHB renal uptake.
Gene_expression (expression) of MCT1 in kidney
15) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (express) of MCT1 in HK-2
16) Confidence 0.56 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Caco-2 cells have been demonstrated to express MCT1, 2 and 4 protein (unpublished data from our lab) with MCT1 expression being the predominant form consistent with expression in the human intestine (19).
Gene_expression (expression) of MCT1 in Caco-2
17) Confidence 0.50 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
In contrast to MCT1, MCT4 is predominantly expressed in highly glycolytic cells such as white muscle and white blood cells suggesting that its physiological function is lactate efflux (17,63).
Gene_expression (expressed) of MCT1 in muscle
18) Confidence 0.50 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.29 Pain Relevance 0
While GHB represents the best studied drug substrate of MCTs, a number of other drugs have been demonstrated to be MCT substrates or inhibitors in various in vitro systems.
Gene_expression (represents) of MCTs
19) Confidence 0.49 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
MCTs are expressed in a wide range of tissues including the liver, intestine, kidney and brain, and as such they have the potential to impact a number of processes contributing to the disposition of xenobiotic substrates.
Gene_expression (expressed) of MCTs in kidney
20) Confidence 0.44 Published 2008 Journal AAPS J Section Abstract Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0

General Comments

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