INT250603

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.23
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (MCTS1) cell cycle (MCTS1) cytoplasm (MCTS1)
Anatomy Link Frequency
kidney 1
MCTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 20 87.56 High High
Bioavailability 12 87.12 High High
Potency 8 64.00 Quite High
agonist 4 54.72 Quite High
gABA 8 25.36 Quite Low
narcan 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 89.60 High High
Overdose 28 83.60 Quite High
Death 8 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Respiratory Failure 4 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Coma 4 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quercetin, a naturally occurring flavonoid, has been demonstrated to inhibit MCT1 and MCT2-mediated l-lactate uptake (58), therefore, we assessed the inhibitory potential of a range of flavonoid compounds.
Negative_regulation (inhibit) of MCT1
1) Confidence 0.36 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.17 Pain Relevance 0.03
Inhibitors of MCT1 fall into three broad categories: (1) bulky or aromatic monocarboxylates which act as competitive inhibitors (e.g. phenyl-pyruvate and ?
Negative_regulation (Inhibitors) of MCT1
2) Confidence 0.35 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.21
As the inhibition of MCTs results in altered GHB uptake in kidney cells, further studies investigated potential strategies for increasing the renal elimination of GHB by administrating the MCT substrates l-lactate and pyruvate (6).
Negative_regulation (inhibition) of MCTs in kidney
3) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.05 Pain Relevance 0
Specifically, inhibition of renal reabsorption via MCTs results in increased renal clearance and decreased drug exposure.
Negative_regulation (inhibition) of MCTs
4) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.07

General Comments

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