INT250604

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 1.20
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (MCTS1) cell cycle (MCTS1) cytoplasm (MCTS1)
Anatomy Link Frequency
developmental stages 1
ROLE 1
kidney 1
MCTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 234 99.46 Very High Very High Very High
Bioavailability 65 95.68 Very High Very High Very High
agonist 17 94.72 High High
Potency 28 35.52 Quite Low
cerebral cortex 1 16.72 Low Low
gABA 33 5.00 Very Low Very Low Very Low
withdrawal 15 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
alcohol 14 5.00 Very Low Very Low Very Low
narcan 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 28 92.56 High High
Apoptosis 14 92.12 High High
Glioma 14 89.48 High High
Neuroblastoma 28 89.04 High High
Skin Cancer 14 84.80 Quite High
Metastasis 14 83.00 Quite High
Breast Cancer 14 79.64 Quite High
Syndrome 14 43.52 Quite Low
Disease 15 38.08 Quite Low
Increased Venous Pressure Under Development 14 34.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies need to address the potential for varied physiological states and xenobiotics to alter MCT1 (or other isoforms) regulation, as this may impact the disposition of both endogenous and exogenous MCT substrates.
Regulation (regulation) of MCT1
1) Confidence 0.51 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.53 Pain Relevance 0
Uptake of butyrate by intestinal epithelia cells is highly dependent on MCT1 expression; alterations in MCT1 levels results in altered uptake of butyrate which is the primary energy source for these cells (36,37).
Regulation (alterations) of MCT1
2) Confidence 0.51 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.21
Influence of MCTs on the Disposition of Other Drugs
Regulation (Influence) of MCTs
3) Confidence 0.45 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Until recently, no information was available regarding the regulation of the orphan MCTs.
Regulation (regulation) of MCTs
4) Confidence 0.45 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.05
Regulation of MCTs has been demonstrated to occur via transcriptional, translational and post-transcriptional mechanisms (26–28).
Regulation (Regulation) of MCTs
5) Confidence 0.45 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
To further explore the influence of MCT1 on GHB renal reabsorption, studies were conducted to assess the modulation of MCT1-mediated GHB transport through the evaluation of potential inhibitors.
Regulation (modulation) of MCT1
6) Confidence 0.37 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
However, based on the expression patterns of MCTs in the kidney, MCT1 is likely the primary isoform responsible for GHB renal uptake.
Regulation (responsible) of MCT1 in kidney
7) Confidence 0.37 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
MCT1 is further regulated by its association with the cell surface glycoprotein CD147, which has a single transmembrane domain with the C-terminus located in the cytosol (48,49).
Regulation (regulated) of MCT1
8) Confidence 0.37 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.50 Pain Relevance 0
ROLE OF MCTs IN DRUG DISPOSITION
Regulation (ROLE) of MCTs in ROLE
9) Confidence 0.33 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.04
Studies have indicated that altered physiological conditions and the presence of xenobiotics may alter the regulation of MCTs, in addition to altered expression at different developmental stages (40–42).
Regulation (regulation) of MCTs in developmental stages
10) Confidence 0.33 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.15
Relatively few studies have been conducted to assess the regulation of MCTs.
Regulation (regulation) of MCTs
11) Confidence 0.33 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.16
While there is a great degree of overlap in the substrate specificity of MCT1 and MCT4, these two isoforms differ in their substrate affinities with MCT4 having lower affinities for a range of monocarboxylates (64).
Regulation (specificity) of MCT1
12) Confidence 0.22 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.16 Pain Relevance 0
Uptake of butyrate by intestinal epithelia cells is highly dependent on MCT1 expression; alterations in MCT1 levels results in altered uptake of butyrate which is the primary energy source for these cells (36,37).
Regulation (results) of MCT1
13) Confidence 0.22 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.21
The impact of MCT substrate/inhibitor specificity and tissue distribution needs to be further examined with respect to drug substrates, and the overall influence of MCTs on drug disposition.
Spec (examined) Regulation (influence) of MCTs
14) Confidence 0.20 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Using in vitro cell culture assays, the transport of gabapentin enacarbil was shown to be dependent on MCT-1 and SMVT.
Regulation (dependent) of MCT-1 associated with gabapentin
15) Confidence 0.15 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 0 Pain Relevance 1.31

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