INT250616

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.90
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC16A4) transmembrane transport (SLC16A4)
Anatomy Link Frequency
HK-2 2
white blood cells 1
Caco-2 1
muscle 1
SLC16A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 14 67.16 Quite High
narcan 7 27.80 Quite Low
depression 7 16.60 Low Low
Central nervous system 7 15.52 Low Low
Glutamate receptor 7 13.52 Low Low
Gabapentin 35 5.00 Very Low Very Low Very Low
Bioavailability 21 5.00 Very Low Very Low Very Low
gABA 14 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 7 97.92 Very High Very High Very High
Metastasis 7 94.44 High High
Disease 7 68.92 Quite High
Increased Venous Pressure Under Development 7 65.68 Quite High
Overdose 49 49.88 Quite Low
Toxicity 7 38.00 Quite Low
Death 14 23.60 Low Low
Coma 7 23.20 Low Low
Unconsciousness 7 22.08 Low Low
Vomiting 14 21.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies, conducted in MDA-MB231 cells (endogenous expression of MCT2 and MCT4) and MDA-MB231 cells transfected with rat MCT1, provided further evidence regarding the specific MCT isoforms involved in GHB renal uptake (10,12).
Gene_expression (expression) of MCT4
1) Confidence 0.27 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Protein expression of MCT1, MCT2 and MCT4 has been demonstrated in human intestinal Caco-2 cells (unpublished data).
Gene_expression (expression) of MCT4 in Caco-2
2) Confidence 0.27 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.03
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (express) of MCT4 in HK-2
3) Confidence 0.27 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (express) of MCT4 in HK-2
4) Confidence 0.24 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
In contrast to MCT1, MCT4 is predominantly expressed in highly glycolytic cells such as white muscle and white blood cells suggesting that its physiological function is lactate efflux (17,63).
Gene_expression (expressed) of MCT4 in muscle
5) Confidence 0.21 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.29 Pain Relevance 0
MCT4 and CD147 expression were induced in MDA-MB231 cells (a highly invasive breast cancer cell line) supporting the metabolic switch to highly glycolytic cells in metastasis and the corresponding increase in lactate efflux (42).
Gene_expression (expression) of MCT4 associated with breast cancer and metastasis
6) Confidence 0.21 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.31 Pain Relevance 0
In contrast to MCT1, MCT4 is predominantly expressed in highly glycolytic cells such as white muscle and white blood cells suggesting that its physiological function is lactate efflux (17,63).
Gene_expression (expressed) of MCT4 in white blood cells
7) Confidence 0.07 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.29 Pain Relevance 0

General Comments

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