INT250619

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC16A7) transmembrane transport (SLC16A7)
Anatomy Link Frequency
HK-2 2
liver 1
Caco-2 1
Brain 1
SLC16A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 14 67.16 Quite High
Glutamate receptor 7 34.16 Quite Low
narcan 7 29.84 Quite Low
depression 7 18.64 Low Low
Central nervous system 7 17.56 Low Low
Gabapentin 35 5.00 Very Low Very Low Very Low
Bioavailability 21 5.00 Very Low Very Low Very Low
gABA 14 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overdose 49 51.92 Quite High
Death 14 40.88 Quite Low
Apoptosis 7 40.44 Quite Low
Toxicity 7 38.00 Quite Low
Glioma 7 37.80 Quite Low
Neuroblastoma 14 37.36 Quite Low
Skin Cancer 7 33.12 Quite Low
Coma 7 25.24 Quite Low
Unconsciousness 7 24.12 Low Low
Vomiting 14 23.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (expression) of MCT2 in HK-2
1) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
MCT1 is expressed at both membranes, although there is greater expression at the BLM; MCT2 is expressed only at the BLM (12).
Gene_expression (expressed) of MCT2
2) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.05 Pain Relevance 0
HK-2 cells express MCT1, MCT2 and MCT4 at both the mRNA and protein level, which agrees with expression patterns in the human kidney cortex (62).
Gene_expression (express) of MCT2 in HK-2
3) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Protein expression of MCT1, MCT2 and MCT4 has been demonstrated in human intestinal Caco-2 cells (unpublished data).
Gene_expression (expression) of MCT2 in Caco-2
4) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.03
Further studies, conducted in MDA-MB231 cells (endogenous expression of MCT2 and MCT4) and MDA-MB231 cells transfected with rat MCT1, provided further evidence regarding the specific MCT isoforms involved in GHB renal uptake (10,12).
Gene_expression (expression) of MCT2
5) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
For example, rodents express higher levels of MCT2 in the liver, while MCT2 protein expression is not detectable in human liver (53).
Gene_expression (expression) of MCT2 in liver
6) Confidence 0.24 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Brain MCT2 expression and cellular localization also appears to be highly species dependent (53–55).
Gene_expression (expression) of MCT2 in Brain
7) Confidence 0.21 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0

General Comments

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