INT250622

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.91
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (MCTS1) cell cycle (MCTS1) cytoplasm (MCTS1)
Anatomy Link Frequency
plasma 1
MCTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 179 99.26 Very High Very High Very High
Bioavailability 32 92.08 High High
gABA 11 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 6 76.44 Quite High
Apoptosis 3 76.00 Quite High
Glioma 3 73.36 Quite High
Neuroblastoma 6 72.92 Quite High
Skin Cancer 3 68.68 Quite High
Restless Legs Syndrome 36 55.20 Quite High
Overdose 21 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Dizziness 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The higher affinity of these acids for MCT1 supports previous studies demonstrating their inhibitory potential towards lactate transport.
MCT1 Binding (affinity) of
1) Confidence 0.40 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.23
The initial association of CD147 and MCT1 is required for the translocation of MCT1 to the plasma membrane (48).
MCT1 Binding (association) of in plasma
2) Confidence 0.40 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.42 Pain Relevance 0
Topology studies suggest that one MCT1 molecule interacts with a single CD147 molecule with subsequent dimerization with another MCT1/CD147 pair.(49).
MCT1 Binding (dimerization) of
3) Confidence 0.31 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.44 Pain Relevance 0
The results indicate that gabapentin enacarbil can be used together with MCT-1, organic cation transporter 2, or other transporter substrates without the need to alter the dose regimes.59,60

Efficacy

MCT-1 Binding (cation) of associated with gabapentin
4) Confidence 0.08 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 0.06 Pain Relevance 0.92

General Comments

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