INT250645

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 9.95
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Samsn1) nucleus (Samsn1)
Anatomy Link Frequency
liver 3
adipose tissue 1
Samsn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 106 100.00 Very High Very High Very High
cytokine 19 97.04 Very High Very High Very High
Inflammatory response 32 90.24 High High
alcohol 16 87.88 High High
Inflammatory mediators 12 72.88 Quite High
imagery 8 60.00 Quite High
fibrosis 25 53.12 Quite High
addiction 2 18.56 Low Low
agonist 11 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 252 100.00 Very High Very High Very High
INFLAMMATION 145 100.00 Very High Very High Very High
Fatty Liver 78 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 63 100.00 Very High Very High Very High
Obesity 56 100.00 Very High Very High Very High
Autoimmune Hepatitis 9 100.00 Very High Very High Very High
Hepatitis 29 99.92 Very High Very High Very High
Metabolic Syndrome 29 99.32 Very High Very High Very High
Parkinson's Disease 4 99.32 Very High Very High Very High
Stress 30 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is considered that fatty liver progresses further to NASH under conditions such as oxidative stress and the action of inflammatory cytokines.
Gene_expression (progresses) of NASH in liver associated with stress, fatty liver, nash(non-alcoholic steatohepatitis), inflammation and cytokine
1) Confidence 0.33 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 1.89 Pain Relevance 0.46
That is why it has been suggested that “obesity” neoantigens are involved in the production of a chronic low-grade inflammation of the adipose tissue and NASH in the development of metabolic syndrome [35].
Gene_expression (production) of NASH in adipose tissue associated with nash(non-alcoholic steatohepatitis), inflammation, obesity and metabolic syndrome
2) Confidence 0.24 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 1.44 Pain Relevance 0.17
In fact, hyperleptinemia is an independent predictor of nonalcoholic steatohepatitis (NASH) in obese humans, and the severity of steatosis, hepatocyte ballooning, as well as nonalcoholic fatty liver disease (NAFLD) activity scores correlate with serum leptin levels [7].
Gene_expression (levels) of NASH in liver associated with fatty liver, nash(non-alcoholic steatohepatitis) and obesity
3) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 1.35 Pain Relevance 0.14
In order to explore the potential effects of specific etiologies of liver disease on hepatic encephalopathy, patients with mixed etiologies or with etiologies represented in low numbers in the current cohort (i.e. hepatitis B, NASH, autoimmune hepatitis, and alpha 1-antithrypsine deficiency) were excluded from further analysis.
Gene_expression (deficiency) of NASH in liver associated with liver disease, nash(non-alcoholic steatohepatitis), autoimmune hepatitis, hepatic encephalopathy and hepatitis
4) Confidence 0.06 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2575200 Disease Relevance 2.39 Pain Relevance 0.03
Patients with NASH cirrhosis were included in the current study only if NASH had been appropriately diagnosed prior to cirrhosis development.
Gene_expression (cirrhosis) of NASH associated with nash(non-alcoholic steatohepatitis) and cirrhosis
5) Confidence 0.06 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2575200 Disease Relevance 1.89 Pain Relevance 0.07
Thus, the upstream events that lead to mitochondrial dysfunction and whether mitochondria are the source of ROS in NAFLD/NASH are largely unknown.
Gene_expression (source) of NASH associated with fatty liver, parkinson's disease and nash(non-alcoholic steatohepatitis)
6) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.99 Pain Relevance 0

General Comments

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