INT250659

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.18 Pain Relevance 0

cytosol (PTEN, PIK3CB) nucleus (PTEN, PIK3CB) cytoplasm (PTEN, PIK3CB) lipid binding (PTEN) cell proliferation (PTEN) signal transduction (PIK3CB)

PTEN (Homo sapiens) PIK3CB (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 Taxol 2 5.00 metalloproteinase 1 5.00 Central nervous system 1 5.00 cytokine 1 5.00 Kinase C 1 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 68 98.72 Cancer 57 96.32 Metastasis 8 89.92 Apoptosis 47 64.72 Disease 9 18.64 Advanced Or Metastatic Breast Cancer 17 8.36 Noninfiltrating Intraductal Carcinoma 6 5.00 Toxicity 5 5.00 Death 5 5.00 Necrosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further data reveal that loss of the PTEN gene (which encodes a phosphatidylinositol phos-phatase, and therefore is a negative regulator of PI3K function) results in constitutive activation of the PI3K pathway and poor patient outcome [28].

Negative_regulation (loss) of PTEN gene Positive_regulation (results) of Positive_regulation (activation) of PI3K

1) Confidence 0.02 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.18 Pain Relevance 0

General Comments

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