INT250660

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PIK3CB, AKT1) cytosol (PIK3CB, AKT1) signal transduction (PIK3CB, AKT1)
nucleus (PIK3CB, AKT1) cell differentiation (AKT1) nucleoplasm (AKT1)
PIK3CB (Homo sapiens)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 47 99.36 Very High Very High Very High
Cancer 57 83.20 Quite High
Breast Cancer 68 70.00 Quite High
Disease 9 65.28 Quite High
Advanced Or Metastatic Breast Cancer 17 55.00 Quite High
Necrosis 4 29.64 Quite Low
Metastasis 8 5.00 Very Low Very Low Very Low
Noninfiltrating Intraductal Carcinoma 6 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, inhibition of one of the three isoforms of Akt, namely Akt 2, by the PI3K inhibitor LY294002 counteracted the activity of fibronectin to protect cells from apoptosis induced by docetaxel.
PI3K Negative_regulation (inhibition) of Akt associated with apoptosis
1) Confidence 0.09 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.83 Pain Relevance 0

General Comments

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