INT250670

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
Taxol 2 97.00 Very High Very High Very High
Kinase C 1 74.96 Quite High
antagonist 1 35.44 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 84 97.84 Very High Very High Very High
Pancreatic Cancer 48 91.72 High High
Breast Cancer 69 91.44 High High
Cancer 74 78.36 Quite High
Adhesions 8 71.88 Quite High
Metastasis 12 44.84 Quite Low
Advanced Or Metastatic Breast Cancer 17 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Noninfiltrating Intraductal Carcinoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of survivin phosphorylation by flavopiridol resulted in loss of survivin expression, and nonphos-phorylatable survivin exhibited accelerated clearance [31].
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of survivin
1) Confidence 0.57 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.45 Pain Relevance 0.09
Moreover, in Panc-1 cells, which had high expression of pFAK, specific inhibition of constitutive FAK phosphorylation by either RNAi or FRNK overexpression decreased the phosphorylation of Akt, reduced the levels of survivin expression and Bad phosphorylation at Ser136 and increased Gem-induced cytotoxicity and apoptosis.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of survivin associated with apoptosis
2) Confidence 0.42 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.72 Pain Relevance 0

General Comments

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