INT250673

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
colon 2
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 81.64 Quite High
Inflammation 19 65.68 Quite High
Crohn's disease 6 52.64 Quite High
Bile 39 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 32 99.68 Very High Very High Very High
Repression 3 84.08 Quite High
Cancer 75 79.32 Quite High
Colitis 1 69.64 Quite High
Disease 19 69.36 Quite High
Targeted Disruption 17 60.96 Quite High
Apoptosis 52 52.80 Quite High
Celiac Disease 1 49.96 Quite Low
Breast Cancer 76 49.56 Quite Low
INFLAMMATION 14 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of P-glycoprotein expression with the specific inhibitor verapamil markedly suppressed survivin mRNA expression, whereas no opposite effect of upregulated P-glycoprotein has been reported.
Negative_regulation (Downregulation) of Gene_expression (expression) of P-glycoprotein
1) Confidence 0.42 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.42 Pain Relevance 0
They further showed, using DNA microarray analyses of nonaffected tissue from IBD patients, that expression of SXR and a known target gene, MDR1, were downregulated in the colon of ulcerative colitis patients.
Negative_regulation (downregulated) of Gene_expression (expression) of MDR1 in colon associated with inflammatory bowel disease
2) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.25 Pain Relevance 0.19

General Comments

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