INT250673

Context Info Confidence 0.42 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.66 Pain Relevance 0.19

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b) transmembrane transport (Abcb1b)

Anatomy Link Frequency colon 2 Abcb1b (Mus musculus)

Pain Link Frequency Relevance Heat agonist 9 81.64 Inflammation 19 65.68 Crohn's disease 6 52.64 Bile 39 5.00 antagonist 8 5.00 Taxol 4 5.00 antidepressant 3 5.00 dexamethasone 2 5.00 Central nervous system 1 5.00 anticonvulsant 1 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 32 99.68 Repression 3 84.08 Cancer 75 79.32 Colitis 1 69.64 Disease 19 69.36 Targeted Disruption 17 60.96 Apoptosis 52 52.80 Celiac Disease 1 49.96 Breast Cancer 76 49.56 INFLAMMATION 14 45.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Downregulation of P-glycoprotein expression with the specific inhibitor verapamil markedly suppressed survivin mRNA expression, whereas no opposite effect of upregulated P-glycoprotein has been reported.

Negative_regulation (Downregulation) of Gene_expression (expression) of P-glycoprotein

1) Confidence 0.42 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.42 Pain Relevance 0

They further showed, using DNA microarray analyses of nonaffected tissue from IBD patients, that expression of SXR and a known target gene, MDR1, were downregulated in the colon of ulcerative colitis patients.

Negative_regulation (downregulated) of Gene_expression (expression) of MDR1 in colon associated with inflammatory bowel disease

2) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.25 Pain Relevance 0.19

General Comments

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