INT250699

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.54
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDK6) nucleus (CDK6) cell cycle (CDK6)
cell division (CDK6) cytoplasm (CDK6)
CDK6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 152 100.00 Very High Very High Very High
rheumatoid arthritis 80 98.88 Very High Very High Very High
Kinase C 1 76.32 Quite High
antagonist 1 74.88 Quite High
Taxol 2 31.36 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 144 100.00 Very High Very High Very High
Rheumatoid Arthritis 80 98.88 Very High Very High Very High
Metastasis 9 84.28 Quite High
Breast Cancer 69 83.08 Quite High
Cancer 83 66.48 Quite High
Apoptosis 69 63.32 Quite High
Colon Cancer 25 50.00 Quite Low
Disease Susceptibility 4 50.00 Quite Low
Disease 38 17.52 Low Low
Autoimmune Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, as the effect sizes for these genes in RA were modest, this study had limited power to detect an association with JIA and MMEL, CDK6 and CCL21 (53%, 69% and 59% respectively).
CDK6 Binding (association) of associated with rheumatoid arthritis and arthritis
1) Confidence 0.33 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.90 Pain Relevance 0.45
We found no significant association with the SNPs in the MMEL, CDK6, CCL21 or the CD40 genes, which may suggest that these genes are RA-specific loci.
CDK6 Neg (no) Binding (association) of associated with rheumatoid arthritis
2) Confidence 0.33 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.89 Pain Relevance 0.45
During G1 phase, the D-type cyclins (generally cyclin D1) are expressed in response to mitogenic signals, and by binding to CDK4 and CDK6, lead to activation of cyclin E/CDK2 and cyclin A/CDK2 in late G1 and S phase.
CDK6 Binding (binding) of
3) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Because cells begin to undergo cell division through mitogenic stimuli, there is induction of synthesis of cyclin D1, which is associated with the kinases CDK4 as well as CDK6.
CDK6 Binding (associated) of
4) Confidence 0.19 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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