INT250702

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 97.12 Very High Very High Very High
Apoptosis 103 93.28 High High
Glioma 26 89.96 High High
Breast Cancer 136 89.44 High High
Disease 18 81.44 Quite High
Cancer 149 81.40 Quite High
Toxicity 10 64.20 Quite High
Advanced Or Metastatic Breast Cancer 34 40.24 Quite Low
Malignant Neoplastic Disease 6 8.80 Low Low
Metastasis 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of ligands induces dimerization of the receptor and activation of the kinase through autophosphorylation, stimulating PI3K/Akt and/or MAPK signalling, various transcription factors (such as STAT-3, c-fos and ELK-1) and enhanced production of VEGF.
Positive_regulation (stimulating) of Gene_expression (production) of PI3K
1) Confidence 0.23 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.75 Pain Relevance 0
Binding of ligands induces dimerization of the receptor and activation of the kinase through autophosphorylation, stimulating PI3K/Akt and/or MAPK signalling, various transcription factors (such as STAT-3, c-fos and ELK-1) and enhanced production of VEGF.
Positive_regulation (enhanced) of Gene_expression (production) of PI3K
2) Confidence 0.23 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.75 Pain Relevance 0
This increased expression of p27Kip1 correlates with decreased expression of p-PI3K, p-AKT, cyclin E, cyclin D1, cyclin D2 and increased expression of FOXO3a protein.
Positive_regulation (increased) of Gene_expression (expression) of PI3K
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0

General Comments

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