INT250703

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
Anatomy Link Frequency
neurons 2
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 3 60.36 Quite High
cerebral cortex 5 5.00 Very Low Very Low Very Low
Somatosensory cortex 4 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 68 98.72 Very High Very High Very High
Cancer 57 96.32 Very High Very High Very High
Metastasis 8 85.36 High High
Apoptosis 47 64.72 Quite High
Disease 9 18.64 Low Low
Advanced Or Metastatic Breast Cancer 17 8.36 Low Low
Disseminated Intravascular Coagulation 10 5.00 Very Low Very Low Very Low
Malformations Of Cortical Development 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Noninfiltrating Intraductal Carcinoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further data reveal that loss of the PTEN gene (which encodes a phosphatidylinositol phos-phatase, and therefore is a negative regulator of PI3K function) results in constitutive activation of the PI3K pathway and poor patient outcome [28].
Negative_regulation (loss) of Negative_regulation (regulator) of PI3K
1) Confidence 0.20 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.16 Pain Relevance 0
Jossin and Goffinet (2007) proposed that inhibition of Pi3K impairs the polarity of neurons so they accumulate in the intermediate zone.
Negative_regulation (impairs) of Negative_regulation (inhibition) of Pi3K in neurons
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.03

General Comments

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