INT250707

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 5.40
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
Anatomy Link Frequency
keratinocyte 4
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 134 98.08 Very High Very High Very High
addiction 12 93.00 High High
agonist 68 92.88 High High
Catecholamine 48 71.16 Quite High
interneuron 4 46.72 Quite Low
gABA 12 46.04 Quite Low
imagery 17 39.44 Quite Low
Kinase C 3 39.28 Quite Low
cerebral cortex 20 5.00 Very Low Very Low Very Low
beta blocker 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 457 99.60 Very High Very High Very High
Adhesions 35 97.12 Very High Very High Very High
Apoptosis 236 96.20 Very High Very High Very High
Glioma 130 91.44 High High
Breast Cancer 137 89.44 High High
Malignant Neoplastic Disease 14 84.44 Quite High
Injury 461 84.16 Quite High
Hyperplasia 13 82.76 Quite High
Pancreatic Cancer 63 82.20 Quite High
Disease 25 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of ligands induces dimerization of the receptor and activation of the kinase through autophosphorylation, stimulating PI3K/Akt and/or MAPK signalling, various transcription factors (such as STAT-3, c-fos and ELK-1) and enhanced production of VEGF.
Gene_expression (production) of PI3K
1) Confidence 0.31 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.75 Pain Relevance 0
As a consequence of dysregulation of the cell cycle, PI3K is over-expressed and activates Akt, which-through phosphorylation of NF-?
Gene_expression (expressed) of PI3K
2) Confidence 0.28 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.62 Pain Relevance 0
2AR-selective antagonist alone increased keratinocyte migratory speed (Figure 2B), this increase was abrogated when the PI3K inhibitor LY294002 was included in the culture incubation, indicating that the PI3K/AKT signaling are downstream of ?
Gene_expression (signaling) of PI3K in keratinocyte associated with antagonist
3) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.22 Pain Relevance 0.41
2AR-selective antagonist alone increased keratinocyte migratory speed (Figure 2B), this increase was abrogated when the PI3K inhibitor LY294002 was included in the culture incubation, indicating that the PI3K/AKT signaling are downstream of ?
Gene_expression (/) of PI3K in keratinocyte associated with antagonist
4) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.22 Pain Relevance 0.40
2AR in keratinocytes attenuates promigratory PI3K/AKT signaling.
Gene_expression (promigratory) of PI3K in keratinocytes
5) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.19 Pain Relevance 0.12
2AR-selective antagonist alone increased keratinocyte migratory speed (Figure 2B), this increase was abrogated when the PI3K inhibitor LY294002 was included in the culture incubation, indicating that the PI3K/AKT signaling are downstream of ?
Gene_expression (included) of PI3K in keratinocyte associated with antagonist
6) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.21 Pain Relevance 0.41
Components of these pathways include genes such as Ras, B-Raf, PI3K, PTEN and Akt that can be mutated or aberrantly expressed in human cancer.
Gene_expression (expressed) of PI3K associated with cancer
7) Confidence 0.18 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.10 Pain Relevance 0
This increased expression of p27Kip1 correlates with decreased expression of p-PI3K, p-AKT, cyclin E, cyclin D1, cyclin D2 and increased expression of FOXO3a protein.
Gene_expression (expression) of PI3K
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0
We also checked for the expression of PI3K and AKT molecules, which dictate the phosphorylation status of p27Kip1 and affect the activity of FOXO proteins.
Gene_expression (expression) of PI3K
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
This increased expression of p27Kip1 correlates with decreased expression of p-PI3K, p-AKT, cyclin E, cyclin D1, cyclin D2 and increased expression of FOXO3a protein.
Gene_expression (expression) of PI3K
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0
As expected, the same treatments decreased the expression of phospho-PI3K and phospho-AKT; the total forms were unaffected.
Gene_expression (expression) of PI3K
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Upon integrin binding to ECM or other stimuli, FAK is autophosphorylated at Tyr397, which provides a high-affinity docking site for several proteins including the p85 subunit of PI3K and the Src kinase.
Gene_expression (kinase) of PI3K
12) Confidence 0.12 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.19 Pain Relevance 0
In the both cells [6]-gingerol could not affect the expression of the regulatory subunit of PI3K, p85?.
Gene_expression (expression) of PI3K
13) Confidence 0.10 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.62 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Gene_expression (expression) of PI3K
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.61 Pain Relevance 0
Increased expression of BLBP in the presence of NRG1 is erbB3/4 and Pi3K dependent
Gene_expression (/) of Pi3K
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Our data suggest that (1) reelin stimulates migration toward the CP via activation of ApoER2, in a Dab1- and Pi3K-dependent but VLDLR- and GSK3?
Gene_expression (dependent) of Pi3K
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.11 Pain Relevance 0
We also show that the effect mediated by NRG1 is erbB3/erbB4 and Pi3K-dependent.
Gene_expression (is) of Pi3K
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
We also show that the effect mediated by NRG1 is erbB3/erbB4 and Pi3K-dependent.
Gene_expression (/) of Pi3K
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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