INT250708

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.09
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
Anatomy Link Frequency
radial 3
keratinocyte 3
neuronal 1
neurons 1
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 99.54 Very High Very High Very High
antagonist 101 98.08 Very High Very High Very High
gABA 21 94.36 High High
addiction 9 93.00 High High
agonist 51 89.40 High High
Catecholamine 36 66.96 Quite High
Taxol 4 59.28 Quite High
imagery 18 59.12 Quite High
Inflammation 7 7.60 Low Low
cerebral cortex 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 136 98.48 Very High Very High Very High
Cancer 280 92.24 High High
Glioma 104 92.24 High High
Hyperinsulinism 1 91.52 High High
Apoptosis 130 91.48 High High
Metastasis 31 85.36 High High
Hyperplasia 10 83.56 Quite High
Renal Cell Carcinoma 29 81.24 Quite High
Injury 349 79.96 Quite High
Burns 225 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combined therapy with IGF-1R inhibitors or inhibitors of PI3K and AKT may therefore be useful.45–47 More studies looking into the mechanisms of resistance to these compounds need to be done as our experience with this agent increases.



Negative_regulation (inhibitors) of PI3K
1) Confidence 0.30 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.23 Pain Relevance 0
Further data reveal that loss of the PTEN gene (which encodes a phosphatidylinositol phos-phatase, and therefore is a negative regulator of PI3K function) results in constitutive activation of the PI3K pathway and poor patient outcome [28].
Negative_regulation (regulator) of PI3K
2) Confidence 0.27 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.07 Pain Relevance 0
In a preclinical study [30], the CDK inhibitor flavopiridol was combined with several transduction inhibitors (cyclo-oxygenase-2 inhibitor SC236, protein kinase C kinase inhibitor, and PI3K inhibitor LY294002).
Negative_regulation (inhibitor) of PI3K associated with kinase c
3) Confidence 0.20 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.47 Pain Relevance 0.11
For the inhibitor study, cells seeded in six well plate were treated with Ly294002 (10 µM), a potent PI3K inhibitor, for 24 hrs.


Negative_regulation (inhibitor) of PI3K
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
2AR-selective antagonist alone increased keratinocyte migratory speed (Figure 2B), this increase was abrogated when the PI3K inhibitor LY294002 was included in the culture incubation, indicating that the PI3K/AKT signaling are downstream of ?
Negative_regulation (inhibitor) of PI3K in keratinocyte associated with antagonist
5) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.20 Pain Relevance 0.41
Directly inhibiting this pathway by incubation of keratinocytes with an inhibitor of PI3K results in decreased cell motility, and induces a stationary cell phenotype, mimicking the findings observed when cells are incubated with specific ?
Negative_regulation (inhibitor) of PI3K in keratinocytes
6) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.20 Pain Relevance 0.12
To determine the contribution of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway to keratinocyte migration, some assays included pretreatment of cells with the PI3K inhibitor, LY294002 (50 ?
Negative_regulation (inhibitor) of PI3K in keratinocyte
7) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.23 Pain Relevance 0.19
These results indicate that the knockdown of cathespin B and uPAR in SNB19 and U251 cells induced G0/G1 arrest with the increased expression of p27Kip1 and FOXO3a and reduced PI3K activity.
Negative_regulation (reduced) of PI3K
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Negative_regulation (downregulation) of PI3K
9) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.62 Pain Relevance 0
Hence, we checked the effect of the PI3K inhibitor, LY294002 (10 µM) on the expression of p-AKT in the total extracts.
Negative_regulation (inhibitor) of PI3K
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
In these conditions, the effect of NRG1 on vimentin+ radial glia was significantly reduced when Pi3K was inhibited.
Negative_regulation (inhibited) of Pi3K in radial
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Jossin and Goffinet (2007) proposed that inhibition of Pi3K impairs the polarity of neurons so they accumulate in the intermediate zone.
Negative_regulation (inhibition) of Pi3K in neurons
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.03
To further assess the influence of intracellular reelin signaling, we used PP2 (10 µM), a Src inhibitor, which blocks Dab1 phosphorylation, as well as LY294002, which by inhibiting PI3K prevents the activation of Akt.
Negative_regulation (inhibiting) of PI3K
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
In the presence of exogenous reelin, neurons move into the cortical plate but only into the lower intermediate zone when Dab1 and Pi3K were inhibited, suggesting that reelin signaling is essential for neuronal migration from the intermediate zone toward the cortical plate.
Negative_regulation (inhibited) of Pi3K in neuronal
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.05
Blocking Pi3K does not alter the morphology of BLBP+ radial glia (Figure 6G,H).
Negative_regulation (Blocking) of Pi3K in radial
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Another possibility is that blockade of Pi3K exhibits a more severe phenotype due to the pleiotropic functions controlled by PI3K/Akt signaling [59].
Negative_regulation (blockade) of Pi3K
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.03
Blockade of erbB3/erbB4 or inhibition of Pi3K signaling prevents the realignment of radial glia induced by NRG1
Negative_regulation (inhibition) of Pi3K in radial
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

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