INT250712

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
Anatomy Link Frequency
keratinocyte 1
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 34 97.56 Very High Very High Very High
agonist 17 95.32 Very High Very High Very High
imagery 4 50.56 Quite High
Catecholamine 12 7.36 Low Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Somatosensory cortex 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 59 98.88 Very High Very High Very High
Apoptosis 47 91.44 High High
Disease 9 80.96 Quite High
Burns 75 79.40 Quite High
Advanced Or Metastatic Breast Cancer 17 70.68 Quite High
Injury 115 60.12 Quite High
Stress 42 50.00 Quite Low
Wound Healing 20 50.00 Quite Low
Necrosis 4 45.32 Quite Low
Breast Cancer 68 39.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the contribution of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway to keratinocyte migration, some assays included pretreatment of cells with the PI3K inhibitor, LY294002 (50 ?
Spec (determine) Regulation (contribution) of PI3K in keratinocyte
1) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0.31 Pain Relevance 0.25
As a consequence of dysregulation of the cell cycle, PI3K is over-expressed and activates Akt, which-through phosphorylation of NF-?
Regulation (dysregulation) of PI3K
2) Confidence 0.12 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.57 Pain Relevance 0
Increased expression of BLBP in the presence of NRG1 is erbB3/4 and Pi3K dependent
Regulation (dependent) of Pi3K
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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