INT250727

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 8.32
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
blood 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 225 99.36 Very High Very High Very High
cytokine 37 97.84 Very High Very High Very High
Osteoarthritis 81 97.64 Very High Very High Very High
Arthritis 6 92.44 High High
antagonist 28 88.56 High High
cva 84 72.64 Quite High
potassium channel 4 40.20 Quite Low
tissue acidosis 2 9.08 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 225 99.78 Very High Very High Very High
Pressure Volume 2 Under Development 40 99.44 Very High Very High Very High
Rheumatoid Arthritis 225 99.36 Very High Very High Very High
Osteoarthritis 81 97.64 Very High Very High Very High
Hemorrhagic Shock 92 96.32 Very High Very High Very High
Acid Base Imbalance 4 96.16 Very High Very High Very High
Injury 112 94.96 High High
Seronegative Spondarthritis 3 92.44 High High
Cv General 2 Under Development 34 87.84 High High
Hemorrhage 106 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This difference may be ascribable to the stronger expression of adrenomedullin receptor (CLR/RAMP2) mRNA and proteins by RA-FLSs than by OA-FLSs [10].
Negative_regulation (expression) of adrenomedullin associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.37 Pain Relevance 0.91
The adhesion-enhancing effect of adrenomedullin is mediated by the adrenomedullin receptor CLR/RAMP
Negative_regulation (effect) of adrenomedullin associated with adhesions
2) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.93 Pain Relevance 0.60
This constitutes the first evidence that the adhesion-enhancing effect of adrenomedullin is specific of RA-FLSs, at least in vitro.


Negative_regulation (effect) of adrenomedullin associated with rheumatoid arthritis and adhesions
3) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.05 Pain Relevance 0.63
The beneficial effect of adrenomedullin/AMBP-1 is associated with downregulation of endothelin-1, which is normally upregulated in hemorrhagic shock [140].
Negative_regulation (effect) of adrenomedullin associated with hemorrhagic shock
4) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 1.16 Pain Relevance 0.09
In contrast, a newly identified vasodilatory peptide, namely adrenomedullin, which is depressed after severe blood loss because of downregulation of adrenomedullin binding protein (AMBP)-1 [137], acts as a circulating hormone that elicits various biologic activities in a paracrine and autocrine manner.
Negative_regulation (depressed) of adrenomedullin in blood associated with pressure volume 2 under development
5) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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