INT250731

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 7.11
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hs (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 120 100.00 Very High Very High Very High
cytokine 98 100.00 Very High Very High Very High
chemokine 12 100.00 Very High Very High Very High
metalloproteinase 6 96.88 Very High Very High Very High
ischemia 12 89.04 High High
tolerance 12 47.36 Quite Low
Inflammatory response 12 38.08 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 184 100.00 Very High Very High Very High
INFLAMMATION 126 100.00 Very High Very High Very High
Hyperglycemia 14 99.32 Very High Very High Very High
Injury 24 98.48 Very High Very High Very High
Sepsis 72 98.12 Very High Very High Very High
Diabetes Mellitus 22 91.12 High High
Obesity 20 91.00 High High
Cv Unclassified Under Development 6 89.04 High High
Coagulation Disorder 12 85.80 High High
Disease 8 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with HS+MES ameliorated hyperglycemia in db/db mice
HS Binding (Treatment) of associated with hyperglycemia and shock
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.64 Pain Relevance 0
Cells were treated for 10 min with HS and MES, and lysates were isolated at the indicated time points.
HS Binding (min) of associated with shock
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.01 Pain Relevance 0
The high-affinity fraction of HS inhibits factor Xa by catalyzing its binding to antithrombin (AT) [1].
HS Binding (binding) of
3) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.46 Pain Relevance 0.30
HS in vivo is found covalently conjugated to specific core proteins as HSPGs and has been found to bind and regulate most of the key mediators of tissue injury and inflammation.
HS Binding (bind) of associated with inflammation and injury
4) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 1.00 Pain Relevance 0.16
For example, soluble HS binds and potentiates activities of transforming growth factor-beta [8] and matrix metalloproteinase [9].
HS Binding (binds) of associated with metalloproteinase
5) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.79 Pain Relevance 0.44
Recently, HS and syndecan, a major cell surface HS proteoglycan (HSPG), have attracted much attention as modulators of various types of inflammation since they have been known to bind and regulate many inflammatory factors, including inflammatory cytokines, through their HS chains [2-5].
HS Binding (bind) of associated with inflammation and cytokine
6) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.62 Pain Relevance 0.40
HS has been found to bind and regulate most of these key mediators.
HS Binding (bind) of
7) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 1.00 Pain Relevance 0.33
Several studies have suggested that binding of chemokines to cell surface HS might regulate the cellular responses and migration of inflammatory cells [6].
HS Binding (binding) of associated with chemokine and inflammation
8) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.60 Pain Relevance 0.42

General Comments

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