INT250742

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC2A2) endosome (SLC2A2) small molecule metabolic process (SLC2A2)
plasma membrane (SLC2A2) carbohydrate metabolic process (SLC2A2) transmembrane transport (SLC2A2)
Anatomy Link Frequency
renal tubule 1
SLC2A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 59.68 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 51 97.84 Very High Very High Very High
Critical Illness 32 80.76 Quite High
Insulin Resistance 4 62.80 Quite High
Hyperglycemia 12 61.88 Quite High
Stress 10 61.08 Quite High
Diabetes Mellitus 13 60.68 Quite High
Chronic Renal Failure 2 54.04 Quite High
Muscle Weakness 1 18.64 Low Low
Acidosis 3 10.96 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin injection in mice provoked a downregulation of the GLUT-2 and SGLT-2 transporters responsible for glucose reabsorption in the convoluted segment of the proximal renal tubule.
Negative_regulation (downregulation) of GLUT-2 in renal tubule
1) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2575562 Disease Relevance 0.86 Pain Relevance 0.03
Glut-2 mRNA tended to decline at 14 and 21 days of coculture, possibly indicating protein deregulation.
Spec (possibly) Negative_regulation (decline) of Glut-2
2) Confidence 0.08 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0

General Comments

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