INT25076

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 41
Total Number 44
Disease Relevance 30.58
Pain Relevance 13.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 17
joint 4
synovial cell 4
neutrophil 4
microglial cell 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1071 100.00 Very High Very High Very High
cytokine 812 100.00 Very High Very High Very High
agonist 70 100.00 Very High Very High Very High
Inflammatory mediators 55 100.00 Very High Very High Very High
Nicotine 41 99.78 Very High Very High Very High
Arthritis 585 99.48 Very High Very High Very High
narcan 7 98.96 Very High Very High Very High
diclofenac 4 98.96 Very High Very High Very High
rheumatoid arthritis 426 98.30 Very High Very High Very High
Opioid 19 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1185 100.00 Very High Very High Very High
Alzheimer's Dementia 158 100.00 Very High Very High Very High
Keratitis 92 100.00 Very High Very High Very High
Gliosis 9 100.00 Very High Very High Very High
Otitis Media 135 99.92 Very High Very High Very High
Injury 363 99.90 Very High Very High Very High
Sepsis 15 99.84 Very High Very High Very High
Targeted Disruption 123 99.74 Very High Very High Very High
Disease 410 99.50 Very High Very High Very High
Arthritis 661 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 in macrophages associated with narcan and opioid
1) Confidence 0.52 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.32
Consistently with the stimulation of microglial cell priming by HS oligosaccharides in the brain, deletion of the innate immune response mediators TLR4 or MyD88 in MPSIIIB mice showed substantial reduction of CD11b staining and of the expression level of IL1?
Negative_regulation (reduction) of in brain Gene_expression (expression) of IL1 in microglial cell
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.39 Pain Relevance 0.04
Intriguingly, it is in line with the initial hallmark observation made in RA synovial cell cultures: the addition of neutralizing anti-TNF antibodies strikingly reduced the production of IL-1 [24].
Negative_regulation (reduced) of Gene_expression (production) of IL-1 in synovial cell associated with rheumatoid arthritis
3) Confidence 0.38 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.39 Pain Relevance 0.23
Neutrophils have been implicated in mediating this effect based on a study in rats where administration of anti-CINC-1 (CXCL1) neutralizing antibodies attenuated neutrophil recruitment and BBB breakdown downstream of intracerebral IL-1?
Negative_regulation (downstream) of Gene_expression (intracerebral) of IL-1 in neutrophil
4) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.17 Pain Relevance 0.10
It is also possible that the capacity of IL-1?
Spec (possible) Negative_regulation (possible) of Gene_expression (capacity) of IL-1
5) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.94 Pain Relevance 0.20
RESULTS: Both morphine (1 x 10(-8) - 1 x 10(-3) mol L-1) and naloxone (50 mumol L-1) inhibited IL-1 production from mouse PM phi primed by sodium thioglycolate.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1
6) Confidence 0.36 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 8701766 Disease Relevance 0 Pain Relevance 0
We found that the aqueous extract of N. procerum leaves (leaf aqueous extract; LAE) inhibits the neutrophil migration, production of inflammatory cytokines interleukin-1 and -6 (IL-1 and IL-6) and the generation of prostaglandin E2 (PGE2) in LPS-induced pleural inflammation in mice.
Negative_regulation (inhibits) of Gene_expression (production) of IL-1 in neutrophil associated with inflammation and cytokine
7) Confidence 0.30 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15930736 Disease Relevance 0.74 Pain Relevance 0.43
Its relevance is underlined by the great efficacy of anti-IL-1 therapy and a total lack of chronic, erosive arthritis in IL-1?
Negative_regulation (lack) of Gene_expression (therapy) of IL-1 associated with arthritis
8) Confidence 0.24 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.56 Pain Relevance 0.29
In a previous study, we showed that abrogated IL-1R1 signaling decreases the responsiveness of microglia and macrophages to injury and lowers the basal and induced levels of cyclooxygenase-2, IL-1 and IL-6 [79]; these results suggest that antagonizing IL-1R1 decreases inflammatory responses after injury.
Negative_regulation (lowers) of Gene_expression (levels) of IL-1 in macrophages associated with inflammatory response and injury
9) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.46 Pain Relevance 0.23
is rapidly induced in experimental models of stroke [2,3] and mice that have decreased IL-1 production are significantly protected from ischemic injury [4-7].
Negative_regulation (decreased) of Gene_expression (production) of IL-1 associated with stroke and injury
10) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.00 Pain Relevance 0.16
Therefore, a possible mechanism to account for the attenuation of TNF mediated joint damage by diacerein could be its inhibition of IL-1 production and hence of the downstream events that lead to production of reactive oxygen species, nitric oxide, and matrix metalloproteases.
Negative_regulation (inhibition) of Gene_expression (production) of IL-1 in joint
11) Confidence 0.23 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400419 Disease Relevance 1.30 Pain Relevance 0.47
The NSAID effect correlated more consistently with piroxicam downregulation of TNF synthesis than that of IL-1.
Negative_regulation (downregulation) of Gene_expression (synthesis) of IL-1
12) Confidence 0.23 Published 1994 Journal J. Rheumatol. Section Body Doc Link 8182646 Disease Relevance 0.08 Pain Relevance 0
APP: amyloid precursor protein; AD: Alzheimer's disease; DEA: diethylamine; FA: formic acid; IL1?
Negative_regulation (formic) of Gene_expression (acid) of IL1 associated with alzheimer's dementia and disease
13) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 1.10 Pain Relevance 0.11
PM, even at the highest concentration used, could not completely inhibit the production of interleukin 1 (IL-1)-like activity, but it caused complete inhibition, in a dose-dependent manner, of the production of IL-2-like activity.
Negative_regulation (inhibit) of Gene_expression (production) of IL-1
14) Confidence 0.18 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2497511 Disease Relevance 0 Pain Relevance 0.50
Early-CIA E/P-selectin mutant mice exhibited significantly elevated levels of IL-1?
Negative_regulation (exhibited) of Gene_expression (levels) of IL-1 associated with arthritis
15) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.76 Pain Relevance 0.31
Increased joint expression of IL-1?
Negative_regulation (joint) of Gene_expression (expression) of IL-1 in joint
16) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.53 Pain Relevance 0.41
Although casp1-/- mice present a reduction in the expression of the mature form of IL-1?
Negative_regulation (reduction) of Gene_expression (expression) of IL-1
17) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.47 Pain Relevance 0.23
, they also reduce the production of other inflammatory cytokines (IL1, IL6, IL8) (Brennan et al 1989).
Negative_regulation (reduce) of Gene_expression (production) of IL1 associated with inflammation and cytokine
18) Confidence 0.13 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673817 Disease Relevance 1.39 Pain Relevance 0.80
Using knockout mice in models of crystal-induced inflammation, macrophages from TLR2 and TLR4 knockout mice showed decreased expression of inflammatory cytokines such as IL-1?
Negative_regulation (decreased) of Gene_expression (expression) of IL-1 in macrophages associated with targeted disruption, inflammation and cytokine
19) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.52 Pain Relevance 0.46
In our experimental conditions, we could not detected mesenteric expression of IL-1?
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of IL-1
20) Confidence 0.11 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.41 Pain Relevance 0.33

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