INT250781

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IRF6, AMIGO2) cytosol (IRF6) cell adhesion (AMIGO2)
plasma membrane (AMIGO2) DNA binding (IRF6) cytoplasm (IRF6)
Anatomy Link Frequency
lung 1
IRF6 (Homo sapiens)
AMIGO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 96.16 Very High Very High Very High
Inflammation 28 95.92 Very High Very High Very High
Inflammatory mediators 2 88.28 High High
Inflammatory marker 4 71.12 Quite High
anesthesia 2 53.76 Quite High
Thoracotomy 2 42.64 Quite Low
Kinase C 28 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 34 100.00 Very High Very High Very High
INFLAMMATION 34 95.92 Very High Very High Very High
Sepsis 36 75.08 Quite High
Lung Injury 26 60.48 Quite High
Adhesions 4 25.48 Quite Low
Pulmonary Edema 4 16.88 Low Low
Stroke 8 5.00 Very Low Very Low Very Low
Coagulation Disorder 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Hemorrhage 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to investigate the effects of rhAPC on sustained LPS-induced ALI in sheep over 24 hours by assessing changes in pulmonary hemodynamics, in extravascular lung water content, in pulmonary vascular permeability index and in gas exchange.
LPS Positive_regulation (induced) of ALI in lung associated with adult respiratory distress syndrome
1) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.73 Pain Relevance 0.22
The present study demonstrates that infused rhAPC ameliorates ovine LPS-induced ALI, as indicated by a decrease in the EVLWI associated with improvements of gas exchange and markers of inflammation and coagulation.
LPS Positive_regulation (induced) of ALI associated with inflammation and adult respiratory distress syndrome
2) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.52 Pain Relevance 0.13

General Comments

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