INT250818

Context Info Confidence 0.12 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 5.06 Pain Relevance 0.20

extracellular space (IFNA2) extracellular region (IFNA2) cell-cell signaling (IFNA2)

Anatomy Link Frequency plasma 2 arm 2 IFNA2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 10 77.92 abdominal pain 4 62.16 Inflammation 13 13.12 fibrosis 5 12.44 corticosteroid 10 5.00 headache 8 5.00 depression 4 5.00 cva 4 5.00 alcohol 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Shock 14 95.72 Skin Cancer 28 93.44 Coagulation Disorder 4 90.76 Adult Respiratory Distress Syndrome 42 89.76 Leukocytosis 2 86.04 Capillary Leak Syndrome 2 86.00 Thrombocytopenia 3 84.24 Cancer 8 78.92 Hypoxia 2 78.68 Syndrome 12 75.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, modified release of interferon-alpha was developed to meet patient expectations for less frequent parenteral drug administrations, and to increase sustained virologic response rates by improving patient adherence as well as more sustained drug concentrations with higher plasma concentrations.

Positive_regulation (increase) of Localization (release) of interferon-alpha in plasma

1) Confidence 0.12 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676642 Disease Relevance 0.43 Pain Relevance 0

The treatment arm consisted of an induction phase of pegIFNa-2b given as 6 ?

Positive_regulation (induction) of Localization (phase) of pegIFNa-2b in arm

2) Confidence 0.09 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963921 Disease Relevance 0.61 Pain Relevance 0

Hantavirus causes an increased release of TNF and alpha interferon and increased MHC I antigen presentation [106,107].

Positive_regulation (causes) of Localization (release) of alpha interferon

3) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.01 Pain Relevance 0.10

Hantavirus causes an increased release of TNF and alpha interferon and increased MHC I antigen presentation [106,107].

Positive_regulation (increased) of Localization (release) of alpha interferon

4) Confidence 0.04 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.01 Pain Relevance 0.10

General Comments

This test has worked.