INT250823

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee joints 1
GAG (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 222 95.40 Very High Very High Very High
Analgesic 6 93.72 High High
Inflammation 39 90.56 High High
Arthritis 45 89.04 High High
Pain 40 85.36 High High
rheumatoid arthritis 7 18.72 Low Low
metalloproteinase 25 11.72 Low Low
cytokine 22 5.00 Very Low Very Low Very Low
Neurobehavioral 7 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 203 95.40 Very High Very High Very High
INFLAMMATION 45 90.56 High High
Arthritis 45 89.04 High High
Pain 38 85.36 High High
Knee Osteoarthritis 34 67.48 Quite High
Obesity 76 50.00 Quite Low
Disease Progression 3 42.24 Quite Low
Injury 16 39.04 Quite Low
Hypertrophy 1 31.80 Quite Low
Disease 17 21.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of FGF8 into the rat knee joints promoted the release of S-GAG from cartilage into the synovial fluid.
Localization (release) of GAG in knee joints
1) Confidence 0.78 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.86 Pain Relevance 0.57
Furthermore, neither S-GAG release nor NOx production were altered by leptin (Figure 6,c).
Localization (release) of GAG
2) Confidence 0.78 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.38 Pain Relevance 0.19
-induced S-GAG release by FGF8 was concentration-dependently suppressed by the addition of anti-FGF8 antibody at 1 to 10 ?
Localization (release) of GAG
3) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
The amount of S-GAG release in the MIA group was 1.6 times higher than that in the saline injection group (P = 0.0014; Figure 6).
Localization (release) of GAG
4) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.25 Pain Relevance 0.12

General Comments

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